ArticleAnnals of gastroenterology
Efficacy of bio-optimized extracts of turmeric and essential fennel oil on the quality of life in patients with irritable bowel syndrome.
Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Herbal Remedies for Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review of Randomized Controlled Trials.Nutrients · 2023Pooled it
- A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.Advances in experimental medicine and biology · 2021Pooled it
- Fennel Tea Has a Region-Specific Effect on the Motility of the Stomach.Neurogastroenterology and motility · 2025Article
- Medicinal Plants for a Healthy Gut Microbiome: Scientific Insights into Modern Herbal Applications.International journal of molecular sciences · 2025Review
- Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies.International journal of molecular sciences · 2025Review
- Article
- Observational
- Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review.Molecules (Basel, Switzerland) · 2023Review
- Non-pharmacologic approaches to treatment of pediatric functional abdominal pain disorders.Frontiers in pediatrics · 2023Review
- Herbal Approaches to Pediatric Functional Abdominal Pain.Children (Basel, Switzerland) · 2022Review
- Turmeric for Treatment of Irritable Bowel Syndrome: A Systematic Review of Population-Based Evidence.Iranian journal of public health · 2022Review
- The effect of a fennel seed extract on the STAT signaling and intestinal barrier function.PloS one · 2022Article
- Supplementation Effect of a Combination of Olive (Antioxidants (Basel, Switzerland) · 2020Article
- PotentNutrients · 2020Article
- Re: A Meta-Analysis of the Clinical Use of Curcumin for Irritable Bowel Syndrome.Journal of clinical medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of herbal products to treat irritable bowel syndrome (IBS), a disease that frequently affects the quality of life (QoL), is still under evaluation. This open pilot study assessed the efficacy of bio-optimized extracts of turmeric and essential fennel oil (Enterofytol®) in IBS patients.
methodsA total of 211 patients (14% diarrhea-predominant, IBS-D; 24% constipation-predominant, IBS-C; 62% mixed, IBS-M) were enrolled by general practitioners and completed questionnaires measuring symptom severity and QoL before and after Enterofytol®, two capsules b.i.d. for one month, followed by two capsules q.d. for another month.
resultsIBS severity index and QoL were inversely related. A significant reduction in the severity index and an improvement in QoL were evident following treatment in all IBS subgroups. IBS-D patients showed the worst clinical picture at entry, with the highest IBS severity index and the lowest QoL score, compared with IBS-C and IBS-M subtypes. IBS-D patients, however, also showed the most pronounced response to therapy, considering both scores. The improvement in the IBS severity index was independent of age and sex.
conclusionsResults from this "real-life" study show that the combination of turmeric and essential fennel oil over two months improves both symptoms and QoL in IBS patients, irrespectively of age, sex, initial severity of symptoms and IBS-subtypes, suggesting a potential role for the natural treatment of IBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.