ArticleWorld journal of gastroenterology2018
Second primary malignancy risk after radiotherapy in rectal cancer survivors.
Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Increased risk of pelvic fracture after radiotherapy in rectal cancer survivors: A propensity matched study.Cancer medicine · 2019Pooled it
- Undifferentiated pelvic sarcoma 5 years post-radiochemotherapy for rectal adenocarcinoma: A case report.Oncology letters · 2026Article
- Long-term risk of second primary malignancy in young women with breast cancer receiving postoperative radiotherapy.Discover oncology · 2026Article
- Subsequent primary cancer risks for non-hereditary colorectal cancer survivors.EClinicalMedicine · 2026Article
- The risk and prognosis factors of second primary malignancies in hepatocellular carcinoma survivors.Discover oncology · 2026Article
- Incidence, Risk and Trends of Multiple Primary Cancers in Patients With Colorectal Cancer: Evidence From the South Australian Cancer Registry.Cancer medicine · 2025Article
- Association of different treatment modalities for rectal cancer and second primary urinary system neoplasms, findings from SEER.Scientific reports · 2025Article
- Association of radiotherapy with secondary pelvic cancers in male patients with rectal cancer.International journal of colorectal disease · 2025Article
- Protocol-based CT-guided brachytherapy for patients with prostate cancer and previous rectal extirpation-a curative approach.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Article
- Analyzing risk factors for second malignancies in early gastric carcinoma from the SEER database.Scientific reports · 2024Article
- Radiation Therapy Changed the Second Malignancy Pattern in Rectal Cancer Survivors.Medicina (Kaunas, Lithuania) · 2023Article
- Risk and prognosis of secondary bladder cancer after post-operative radiotherapy for gynecological cancer.Bosnian journal of basic medical sciences · 2022Article
- Increased risk of secondary bladder cancer after radiation therapy for endometrial cancer.Scientific reports · 2022Article
- Postoperative radiotherapy might be a risk factor for second primary lung cancer: A population-based study.Frontiers in oncology · 2022Article
- Risk and prognosis of secondary bladder cancer after radiation therapy for pelvic cancer.Frontiers in oncology · 2022Article
- Preoperative Short-Course Radiotherapy and Surgery versus Surgery Alone for Patients with Rectal Cancer: A Propensity Score-Matched Analysis at 18-Year Follow-Up.Biomedicines · 2021Article
- Association of Radiotherapy for Rectal Cancer and Second Gynecological Malignant Neoplasms.JAMA network open · 2021Article
- Identification of Patients with Locally Advanced Rectal Cancer in Whom Preoperative Radiotherapy Can Be Omitted: A Multicenter Retrospective Study at Yokohama Clinical Oncology Group (YCOG1307).Journal of the anus, rectum and colon · 2021Article
- [Urinary bladder cancer as a late sequela of spinal cord injury : Decision-making aids for assessment of this causal association].Der Urologe. Ausg. A · 2020Review
- Risk and Prognosis of Secondary Bladder Cancer After Radiation Therapy for Rectal Cancer: A Large Population-Based Cohort Study.Frontiers in oncology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate second primary malignancy (SPM) risk after radiotherapy in rectal cancer survivors.
methodsWe used Taiwan's National Health Insurance Research Database to identify rectal cancer patients between 1996 and 2011. Surgery-alone, preoperative short course, preoperative long course, and post-operative radiotherapy groups were defined. The overall and site-specific SPM incidence rates were compared among the radiotherapy groups by multivariate Cox regression, taking chemotherapy and comorbidities into account. Sensitivity tests were performed for attained-year adjustment and long-term survivors analysis.
resultsA total of 28220 patients were analyzed. The 10-year cumulative SPM incidence was 7.8% [95% confidence interval (CI): 7.2%-8.2%] using a competing risk model. The most common sites of SPM were the lung, liver, and prostate. Radiotherapy was not associated with increased SPM risk in multi-variate Cox model (hazard ratio = 1.05, 95%CI: 0.91-1.21,
conclusionIn this large population-based cohort study, we demonstrated that radiotherapy had no increase in SPM.
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