ArticleScientific reports2018
Modelling of Cellular Survival Following Radiation-Induced DNA Double-Strand Breaks.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
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- The Mayo Clinic Florida Microdosimetric Kinetic Model of Clonogenic Survival: Application to Various Repair-Competent Rodent and Human Cell Lines.International journal of molecular sciences · 2022Article
- Comprehensive comparison of local effect model IV predictions with the particle irradiation data ensemble.Medical physics · 2022Article
- Biological Effectiveness of Ion Beam forFrontiers in oncology · 2022Article
- Update of the particle irradiation data ensemble (PIDE) for cell survival.Journal of radiation research · 2021Article
- A Mathematical Radiobiological Model (MRM) to Predict Complex DNA Damage and Cell Survival for Ionizing Particle Radiations of Varying Quality.Molecules (Basel, Switzerland) · 2021Article
- Scaling parameter of the lethal effect of mammalian cells based on radiation-induced OH radicals: effectiveness of direct action in radiation therapy.Journal of radiation research · 2021Article
- Low Repair Capacity of DNA Double-Strand Breaks Induced by Laser-Driven Ultrashort Electron Beams in Cancer Cells.International journal of molecular sciences · 2020Article
- Hi-C implementation of genome structure for in silico models of radiation-induced DNA damage.PLoS computational biology · 2020Article
- A model of radiation action based on nanodosimetry and the application to ultra-soft X-rays.Radiation and environmental biophysics · 2020Article
- Standardizing Monte Carlo simulation parameters for a reproducible dose-averaged linear energy transfer.The British journal of radiology · 2020Article
- Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo Simulations.Cancers · 2020Review
- Optimization of treatment planning for hypoxic tumours and re-modulation of radiation intensity in heavy-ion radiotherapy.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A mechanistic model of cellular survival following radiation-induced DNA double-strand breaks (DSBs) was proposed in this study. DSBs were assumed as the initial lesions in the DNA of the cell nucleus induced by ionizing radiation. The non-homologous end-joining (NHEJ) pathway was considered as the domain pathway of DSB repair in mammalian cells. The model was proposed to predict the relationship between radiation-induced DSBs in nucleus and probability of cell survival, which was quantitatively described by two input parameters and six fitting parameters. One input parameter was the average number of primary particles which caused DSB, the other input parameter was the average number of DSBs yielded by each primary particle that caused DSB. The fitting parameters were used to describe the biological characteristics of the irradiated cells. By determining the fitting parameters of the model with experimental data, the model is able to estimate surviving fractions for the same type of cells exposed to particles with different physical parameters. The model further revealed the mechanism of cell death induced by the DSB effect. Relative biological effectiveness (RBE) of charged particles at different survival could be calculated with the model, which would provide reference for clinical treatment.
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