ArticleProstate cancer and prostatic diseases2019
Higher baseline dietary fat and fatty acid intake is associated with increased risk of incident prostate cancer in the SABOR study.
Article in Prostate cancer and prostatic diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 46 citations in OpenAlex.
- Prevention of Myc-Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane.Molecular carcinogenesis · 2026Article
- Joint Biochemical and Genetic Prostate Cancer Risk Stratification.The Journal of urology · 2026Article
- Fatty acid diet and prostate cancer: a treasure hunt or a wild goose chase?Prostate cancer and prostatic diseases · 2025Review
- Broadband Collision-Induced Dissociation Mass Spectrometry Imaging.Journal of the American Society for Mass Spectrometry · 2025Article
- Dietary impacts on prostate cancer immunotherapy.Immunotherapy · 2025Review
- The association between ultra-processed foods intake and the odds of prostate cancer: a case-control study.Journal of health, population, and nutrition · 2025Article
- The Impact of Diet and Nutrition on Prostate Cancer - Food for Thought?Current oncology reports · 2025Review
- The impact of diet and gut microbiota on development, treatment, and prognosis in prostate cancer.Frontiers in nutrition · 2025Review
- Longitudinal anemia status and risk for adverse outcomes in former smokers with COPD.Respiratory research · 2024Article
- Review
- The Impact of Nutrient Supply on Prostate Cancer Risk Worldwide.Nutrients · 2023Article
- Nutrigenomics and microbiome shaping the future of personalized medicine: a review article.Journal, genetic engineering & biotechnology · 2023Review
- Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men.Nature communications · 2023Article
- The Modulatory Effects of Fatty Acids on Cancer Progression.Biomedicines · 2023Review
- Association Between Dietary Fatty Acid Pattern and Risk of Oral Cancer.Frontiers in nutrition · 2022Article
- Cholesterol Promotes Colorectal Cancer Growth by Activating the PI3K/AKT Pathway.Journal of oncology · 2022Article
- How cancer cells remodel lipid metabolism: strategies targeting transcription factors.Lipids in health and disease · 2021Review
- Dietary Fats, Serum Cholesterol and Liver Cancer Risk: A Systematic Review and Meta-Analysis of Prospective Studies.Cancers · 2021Review
- INPP4B protects from metabolic syndrome and associated disorders.Communications biology · 2021Article
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12 authors at 5 institutions in 1 country.
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Abstract
backgroundTo study the association of nutrient intake measured by baseline food frequency questionnaire and risk of subsequent prostate cancer (PCa) in the SABOR (San Antonio Biomarkers of Risk) cohort study.
methodsAfter IRB approval, more than 1903 men enrolled in a prospective cohort from 2000 to 2010 as part of the SABOR clinical validation site for the National Cancer Institute Early Detection Research Network. Food and nutrient intakes were calculated using a Food Frequency Questionnaire. Cox proportional hazards modeling and covariate-balanced propensity scores were used to assess the associations between all nutrients and PCa.
resultsA total of 229 men were diagnosed with PCa by prostate biopsy. Among all nutrients, increased risk of PCa was associated with intake of dietary fat scaled by the total caloric intake, particularly saturated fatty acid (SFA) [HR 1.19; 95% CI, 1.07-1.32), P value < 0.001, False discovery rate (FDR) 0.047] and trans fatty acid (TFA) [HR per quintile 1.21; (95% CI) (1.08-1.35), P < 0.001, FDR 0.039]. There was an increased risk of PCa with increasing intake of monounsaturated fatty acid (MUFA) (HR per quintile 1.14; 95% CI 1.03-1.27, P = 0.01, FDR 0.15) and cholesterol [HR per quintile 1.13; 95% confidence interval (95% CI) (1.02-1.26), P-value 0.02, FDR 0.19].
conclusionAfter examining a large, population-based cohort for PCa diagnosis, we identified dietary total fat and certain fatty acids as associated with increased risk of PCa. We found no factors that were protective from PCa. Dietary modification of fatty acid intake may reduce risk of PCa.
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