Evidence map›Paper›PMID 30385834›Full record

ArticleThe American journal of gastroenterology2018

Smoking and Other Risk Factors in Individuals With Synchronous Conventional High-Risk Adenomas and Clinically Significant Serrated Polyps.

Joseph C Anderson, Audrey H Calderwood, Brock C Christensen, Christina M Robinson, Christopher I Amos, Lynn Butterly

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  10. Anatomical Distribution of Polyps Is Different for Men and Women With Positive Stool Tests.JGH open : an open access journal of gastroenterology and hepatology · 2025
    Article
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  15. Article
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  17. [Obesity and Colorectal Cancer].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2023
    Review
  18. Serrated Polyp Yield at Colonoscopy in Patients with Positive FIT, Positive mt-sDNA, and Colonoscopy Only: Data from the New Hampshire Colonoscopy Registry.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
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  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joseph C AndersonDepartment of Veterans Affairs Medical Center, White River Junction, Hartford, VT, USA. The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Section of Gastroenterology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. Department of Community and Family Medicine, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Baylor College of Medicine, Houston, TX, USA. Lynn Butterly is the senior author on the paper and the Director of the New Hampshire Colonoscopy Registry.
Audrey H CalderwoodDepartment of Veterans Affairs Medical Center, White River Junction, Hartford, VT, USA. The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Section of Gastroenterology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. Department of Community and Family Medicine, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Baylor College of Medicine, Houston, TX, USA. Lynn Butterly is the senior author on the paper and the Director of the New Hampshire Colonoscopy Registry.
Brock C ChristensenDepartment of Veterans Affairs Medical Center, White River Junction, Hartford, VT, USA. The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Section of Gastroenterology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. Department of Community and Family Medicine, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Baylor College of Medicine, Houston, TX, USA. Lynn Butterly is the senior author on the paper and the Director of the New Hampshire Colonoscopy Registry.
Christina M RobinsonDepartment of Veterans Affairs Medical Center, White River Junction, Hartford, VT, USA. The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Section of Gastroenterology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. Department of Community and Family Medicine, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Baylor College of Medicine, Houston, TX, USA. Lynn Butterly is the senior author on the paper and the Director of the New Hampshire Colonoscopy Registry.
Christopher I AmosDepartment of Veterans Affairs Medical Center, White River Junction, Hartford, VT, USA. The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Section of Gastroenterology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. Department of Community and Family Medicine, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Baylor College of Medicine, Houston, TX, USA. Lynn Butterly is the senior author on the paper and the Director of the New Hampshire Colonoscopy Registry.
Lynn ButterlyDepartment of Veterans Affairs Medical Center, White River Junction, Hartford, VT, USA. The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Section of Gastroenterology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. Department of Community and Family Medicine, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Baylor College of Medicine, Houston, TX, USA. Lynn Butterly is the senior author on the paper and the Director of the New Hampshire Colonoscopy Registry.
Dartmouth College · USLynn University · US

Funding

Variations in Colonoscopy Screening: A Population Based StudyR01CA131141 · NCI · DARTMOUTH COLLEGE · PI BUTTERLY, LYNN F · 2008 to 2012
$4.5M
NCI NIH HHS R01 CA131141
6 · The paper itself

Abstract

BACKGROUND AND

aimsSerrated polyps (SPs) and conventional high-risk adenomas (HRAs) derive from two distinct biological pathways but can also occur synchronously. Adults with synchronous SPs and adenomas have been shown to be a high-risk group and may have a unique risk factor profile that differs from adults with conventional HRAs alone. We used the population-based New Hampshire Colonoscopy Registry (NHCR) to examine the risk profile of individuals with synchronous conventional HRAs and SPs.

methodsOur study population included 20,281 first time screening colonoscopies from asymptomatic NHCR participants 40 years or older between 2004-15. Exams were categorized by findings: (1) normal, (2) HRA only (adenomas ≥ 1 cm, villous, high grade dysplasia, multiple adenomas ( > 2) and adenocarcinoma), (3) clinically significant SP (CSSP) only (any hyperplastic polyp ≥ 1 cm, sessile serrated adenomas/polyps or traditional serrated adenomas), and (4) synchronous HRA + CSSP. Risk factors examined included exposure of interest, smoking (never, past, and current/pack years), as well as age, sex, alcohol, education, and family history of colorectal cancer (CRC). Multivariable unconditional logistic regression tested the relation of risk factors with having synchronous HRA + CSSP versus having a normal exam or HRA alone.

resultsAmong NHCR participants with 18,354 screening colonoscopies (with complete smoking, sex, bowel preparation data, and adequate preparation) there were 16,495 normal; 1309 HRA alone; 461 CSSP alone, and 89 synchronous HRA + CSSP. Current smoking was associated with an almost threefold increased risk for HRA or CSSP, and an eightfold risk for synchronous HRA + CSSP (aOR = 8.66; 95% CI: 4.73-15.86) compared to normal exams. Adults with synchronous HRA + CSSP were threefold more likely to be current smokers than those with HRA alone (aOR = 3.27; 95% CI:1.74-6.16).

conclusionsOur data suggest that current smokers may be at a higher risk for synchronous CSSP + HRA even when compared to having HRA alone.

Indexed as

AdenomaAgedCohort StudiesColonColonic PolypsColonoscopyColorectal NeoplasmsFemaleHumansMaleMass ScreeningMiddle AgedNeoplasms, Multiple PrimaryNew HampshireRegistriesRisk Factors

Identifiers

PMID30385834
PMCPMC6768665
OpenAlexW2898636550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.