Evidence map›Paper›PMID 30385779›Full record

ArticleScientific reports2018

Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure.

Phung N Thai, Daniel J Daugherty, Bert J Frederich, Xiyuan Lu, Wenbin Deng, Donald M Bers, Elena N Dedkova, Saul Schaefer

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 56 citations in OpenAlex.

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  14. Cholesterol-dependent enzyme activity of human TSPO1.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  17. Imaging Inflammation Past, Present, and Future: Focus on Cardioimmunology.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  18. Article
  19. Article
  20. Functional remodelling of perinuclear mitochondria alters nucleoplasmic CaPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Phung N ThaiDepartment of Internal Medicine, Cardiovascular Medicine, University of California, Davis, CA, USA.
Daniel J DaughertyDepartment of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
Bert J FrederichDepartment of Internal Medicine, Cardiovascular Medicine, University of California, Davis, CA, USA.
Xiyuan LuDepartment of Pharmacology, University of California, Davis, CA, USA.
Wenbin DengDepartment of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
Donald M BersDepartment of Pharmacology, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0002-2237-9483
Elena N DedkovaDepartment of Pharmacology, University of California, Davis, CA, USA. ededkova@ucdavis.edu.ORCID http://orcid.org/0000-0002-0601-9816
Saul SchaeferDepartment of Internal Medicine, Cardiovascular Medicine, University of California, Davis, CA, USA. sschaefer@ucdavis.edu.ORCID http://orcid.org/0000-0001-7689-8134
University of California, Davis · USUniversity of California System · US

Funding

Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Molecular examination of mitochondrial calcium controlR01HL132831 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BERS, DONALD M, MOLKENTIN, JEFFERY D · 2016 to 2024
$5.9M
IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR01HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1986 to 2018
$3.8M
In Vivo Ultrasound Imaging System (VEVO 2100, VisualSonics)S10OD010389 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2013 to 2013
$397k
NHLBI NIH HHS R01 HL030077NHLBI NIH HHS R01 HL132831NHLBI NIH HHS T32 HL086350NIH HHS S10 OD010389
6 · The paper itself

Abstract

Heart failure (HF) is characterized by abnormal mitochondrial calcium (Ca

Indexed as

Blood PressureAnimalsBiomarkersCalciumCardiomegalyDisease Models, AnimalGene Expression RegulationHeart FailureHeart Function TestsMiceMice, KnockoutMitochondria, HeartMyocytes, CardiacReactive Oxygen SpeciesReceptors, GABAVentricular RemodelingBiomarkersBzrp protein, mouseCalciumReactive Oxygen SpeciesReceptors, GABA

Identifiers

PMID30385779
PMCPMC6212397
OpenAlexW2898518954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.