ArticleNature communications2018
Transcriptional read-through of the long non-coding RNA SVALKA governs plant cold acclimation.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 111 papers, 1 of them a synthesis that pooled it.
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Who cites it
111 citing papers in PubMed, 1 synthesis or guideline pooled it, 252 citations in OpenAlex.
- Antisense Transcription in Plants: A Systematic Review and an Update on cis-NATs of Sugarcane.International journal of molecular sciences · 2022Pooled it
- lncRNA62732 acts as an eTM of miR9778 to regulate TaHAK18-5B and mediate the potassium deficiency response in wheat.The New phytologist · 2026Article
- Identifying heat shock-responsive lncRNAs in wheat during grain filling.BMC plant biology · 2026Article
- Temperature regulation in plants: From molecular mechanisms to climate-resilient crop improvement.Journal of integrative plant biology · 2026Review
- Engineering climate-resilient horticultural crops: advances in transcriptional regulation, genome editing, and synthetic networks.Horticulture research · 2026Article
- GhPsbO breaks the growth-immunity tradeoff by simultaneously promoting growth and defense in cotton.The Plant cell · 2026Article
- RNA regulation in plants.Science China. Life sciences · 2026Review
- Genome-Wide Analysis of the lncRNAs and miRNAs Involved in Flower Development in Radish.Plant direct · 2026Article
- In vivo RNA structure influences the translation and stability of plant long non-coding RNAs.Plant communications · 2026Article
- Chromatin remodeling at the C-REPEAT BINDING FACTOR cluster controls growth retardation at low ambient temperature.The Plant cell · 2026Article
- Unraveling the multifaceted roles of theForestry research · 2026Article
- Article
- Advances of Long Non-Coding RNA in Perennial Plants: Development and Stress Responses.Plants (Basel, Switzerland) · 2025Review
- Cis- and trans-action of the cold-induced lncRNAs, SVALKA and SVALNA, regulate CBF1 and CBF3 in Arabidopsis.EMBO reports · 2025Article
- Chromatin retained MUSHER lncRNA integrates ABA and DOG1 signalling pathways to enhance Arabidopsis seeds dormancy.Nature communications · 2025Article
- Plant long noncoding RNAs: why do we not know more?Biological research · 2025Review
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- The nuclear exosome subunit HEN2 acts independently of the core exosome to assist transcription in Arabidopsis.Plant physiology · 2024Article
- miR827 orchestrates the regulation of SPX-MFS1 and SPX-MFS5 with the assistance of lncRNA767 to enhance phosphate starvation tolerance and maize development.Plant biotechnology journal · 2024Article
- Molecular Mechanisms Underlying Freezing Tolerance in Plants: Implications for Cryopreservation.International journal of molecular sciences · 2024Review
51 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most DNA in the genomes of higher organisms does not encode proteins, yet much is transcribed by RNA polymerase II (RNAPII) into long non-coding RNAs (lncRNAs). The biological significance of most lncRNAs is largely unclear. Here, we identify a lncRNA (SVALKA) in a cold-sensitive region of the Arabidopsis genome. Mutations in SVALKA affect CBF1 expression and freezing tolerance. RNAPII read-through transcription of SVALKA results in a cryptic lncRNA overlapping CBF1 on the antisense strand, termed asCBF1. Our molecular dissection reveals that CBF1 is suppressed by RNAPII collision stemming from the SVALKA-asCBF1 lncRNA cascade. The SVALKA-asCBF1 cascade provides a mechanism to tightly control CBF1 expression and timing that could be exploited to maximize freezing tolerance with mitigated fitness costs. Our results provide a compelling example of local gene regulation by lncRNA transcription having a profound impact on the ability of plants to appropriately acclimate to challenging environmental conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.