Evidence map›Paper›PMID 30385709›Full record

ArticleThe Journal of rheumatology2019

HLA-DRB1 Amino Acid Positions and Residues Associated with Antibody-positive Rheumatoid Arthritis in Black South Africans.

Nimmisha Govind, Richard J Reynolds, Bridget Hodkinson, Claudia Ickinger, Michele Ramsay, S Louis Bridges, Mohammed Tikly

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Frontiers in immunology · 2025
    Article
  4. Article
  5. Genetics of rheumatoid arthritis.Seminars in immunopathology · 2022
    Review
  6. Rheumatic diseases in Africa.Nature reviews. Rheumatology · 2021
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Nimmisha GovindFrom the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa. nimmisha.govind@gmail.com.ORCID 0000-0003-2900-1042
Richard J ReynoldsFrom the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-6419-7779
Bridget HodkinsonFrom the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-5360-9483
Claudia IckingerFrom the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-1295-6424
Michele RamsayFrom the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-4156-4801
S Louis BridgesFrom the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-3785-1389
Mohammed TiklyFrom the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-7850-3538
University of the Witwatersrand · ZAUniversity of Cape Town · ZA

Funding

Discovering Novel Genetic and Environmental Risk Factors for RA in African AmericK01AR060848 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI REYNOLDS, RICHARD JAMES · 2011 to 2015
$641k
NIAMS NIH HHS K01 AR060848
6 · The paper itself

Abstract

objectiveTo investigate the association of specific amino acid positions, residues, and haplotypes of HLA-DRB1 in black South Africans with autoantibody-positive rheumatoid arthritis (RA).

methodsHigh-resolution

resultsOf the 29 amino acid positions examined, positions 11, 13, and 33 (permutation p = 3.4

conclusionAutoantibody-positive RA in black South Africans is associated with histidine at position 13 and valine at position 11 of HLA-DRB1, and haplotypes with valine at position 11 conferred the highest risk; conversely, serine at position 11 conveyed protection.

Indexed as

AdultAgedAllelesAmino AcidsAnti-Citrullinated Protein AntibodiesArthritis, RheumatoidBlack or African AmericanCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHaplotypesHLA-DRB1 ChainsHumansMaleMiddle AgedAmino AcidsAnti-Citrullinated Protein AntibodiesHLA-DRB1 ChainsRheumatoid FactorANTICITRULLINATED PEPTIDE ANTIBODYHAPLOTYPESSERINEVALINE

Identifiers

PMID30385709
PMCPMC6820986
OpenAlexW2899276399

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.