Evidence map›Paper›PMID 30385649›Full record

Trial reportTobacco control2019

Correlates of support for a nicotine-reduction policy in smokers with 6-week exposure to very low nicotine cigarettes.

Rachel L Denlinger-Apte, Jennifer W Tidey, Joseph S Koopmeiners, Dorothy K Hatsukami, Tracy T Smith, Lauren R Pacek, F Joseph McClernon, Eric C Donny

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Tobacco control, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01681875 (Project 1, Study 1), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01681875 nacompletednot on this map

Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes

TypeinterventionalSponsorWake Forest University Health SciencesRan2013 to 2014Enrolled839ConditionsTobacco DependenceArmsvery low nicotine content cigarettes
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. "I'm Bored and I'm Stressed": A Qualitative Study of Exclusive Smokers, ENDS Users, and Transitioning Smokers or ENDS Users in the Time of COVID-19.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
    Article
  5. Perceptions of Nicotine Reduction Policy in the United States: A Qualitative Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rachel L Denlinger-ApteDepartment of Behavioral and Social Sciences, Brown University School of Public Health, Brown University, Providence, Rhode Island, USA.
Jennifer W TideyDepartment of Behavioral and Social Sciences, Brown University School of Public Health, Brown University, Providence, Rhode Island, USA.
Joseph S KoopmeinersDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Dorothy K HatsukamiMasonic Cancer Center and Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA.
Tracy T SmithDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Lauren R PacekDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
F Joseph McClernonDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Eric C DonnyBaptist Comprehensive Cancer Center and Department of Physiology and Pharmacology, Wake Forest University, Winston-Salem, North Carolina, USA.

Funding

VERY LOW NICOTINE CIGARETTES IN SMOKERS WITH SCHIZOPHRENIAU54DA031659 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI COLBY, SUZANNE M · 2011 to 2022
$64.7M
University of Vermont Tobacco Center of Regulatory ScienceU54DA036114 · NIDA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HIGGINS, STEPHEN T · 2018 to 2022
$19.4M
Assessing Tobacco Product Choice When the Cost of Menthol Cigarettes IncreasesR36DA045183 · NIDA · BROWN UNIVERSITY · PI DENLINGER-APTE, RACHEL · 2018 to 2019
$107k
NIDA NIH HHS R36 DA045183NIDA NIH HHS U54 DA031659NIDA NIH HHS U54 DA036114
6 · The paper itself

Abstract

backgroundThe US Food and Drug Administration recently issued an advanced notice of proposed rule-making for reducing the nicotine content in cigarettes to a minimally addictive level. Very little is known about whether use of very low nicotine content (VLNC) cigarettes affects support for a nicotine reduction policy.

objectiveThis study examined the effects of using VLNC versus usual brand (UB) cigarettes on support for a nicotine reduction policy and determined whether participant characteristics and responses to VLNC cigarettes were associated with policy support.

methodsParticipants from a cigarette trial who were assigned to either 0.4 mg nicotine/g tobacco research cigarettes or their UB for 6 weeks were asked about their support for the policy. χ

findingsPolicy support did not differ by condition. After 6 weeks of using VLNC cigarettes, 50% of participants supported the policy, 26% opposed and 24% responded 'Don't Know'. Support was higher among those adherent to smoking only VLNC cigarettes (65%) compared with those who were non-adherent (44%). Older participants and those interested in quitting had increased odds of support. Cigarette satisfaction, perceived harm and perceived nicotine content were not significantly associated with support.

conclusionsSmoking VLNC cigarettes did not affect support for a nicotine reduction policy. Understanding predictors of policy support and opposition will help public health officials to maximise the public health acceptance and impact of this policy (ClinicalTrials.gov Identifier: NCT01681875 Post-Results).

Indexed as

Tobacco ProductsCigarette SmokingDouble-Blind MethodFemaleHumansMaleNicotinePublic HealthPublic PolicySmokersSmoking CessationTobacco Use Cessation DevicesNicotineharm reductionnicotinepublic policy

Identifiers

PMID30385649
PMCPMC6482068

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.