ArticleThe American journal of the medical sciences2018
The Use of Microbiome Restoration Therapeutics to Eliminate Intestinal Colonization With Multidrug-Resistant Organisms.
Article in The American journal of the medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Antimicrobial-resistant Escherichia Coli and Salmonella in poultry production and spread and effect in the one health framework.Poultry science · 2026Review
- The Role of the Gut, Urine, and Vaginal Microbiomes in the Pathogenesis of Urinary Tract Infection in Women and Consideration of Microbiome Therapeutics.Open forum infectious diseases · 2024Review
- Research advances on short-chain fatty acids in gastrointestinal acute graft-Therapeutic advances in hematology · 2024Review
- Burden and Management of Multi-Drug Resistant Organism Infections in Solid Organ Transplant Recipients Across the World: A Narrative Review.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Gut Microbiota Modulation and Prevention of Dysbiosis as an Alternative Approach to Antimicrobial Resistance: A Narrative Review.The Yale journal of biology and medicine · 2022Review
- Antimicrobial resistance: new insights and therapeutic implications.Applied microbiology and biotechnology · 2022Review
- Immunological consequences of microbiome-based therapeutics.Frontiers in immunology · 2022Review
- Selective Intestinal Decontamination as a Method for Preventing Infectious Complications (Review).Sovremennye tekhnologii v meditsine · 2021Review
- Safety and Stability of Two Potentially Probiotic Lactobacillus Strains After In Vitro Gastrointestinal Transit.Probiotics and antimicrobial proteins · 2020Article
- Antibacterial Effectiveness of Fecal Water and inMicroorganisms · 2020Article
- Bacterial, Gut Microbiome-Modifying Therapies to Defend against Multidrug Resistant Organisms.Microorganisms · 2020Review
- The gut microbiota in transplant patients.Blood reviews · 2020Review
- Gut Microbiota Modulation for Multidrug-Resistant Organism Decolonization: Present and Future Perspectives.Frontiers in microbiology · 2019Review
- The role of the human gut microbiota in colonization and infection with multidrug-resistant bacteria.Gut microbesReview
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Antibiotic resistance (AR) has been described by the World Health Organization as an increasingly serious threat to global public health. Many mechanisms of AR have become widespread due to global selective pressures such as widespread antibiotic use. The intestinal tract is an important reservoir for many multidrug-resistant organisms (MDROs), and next-generation sequencing has expanded understanding of the resistome, defined as the comprehensive sum of genetic determinants of AR. Intestinal decolonization has been explored as a strategy to eradicate MDROs with selective digestive tract decontamination and probiotics being notable examples with mixed results. This review focuses on fecal microbiota transplantation and the early evidence supporting its efficacy in decolonizing MDROs and potential mechanisms of action to reduce AR genes. Current evidence suggests that fecal microbiota transplantation may have promise in restoring healthy microbial diversity and reducing AR, and clinical trials are underway to better characterize its safety and efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.