ReviewNutrients2018
Malnutrition and Fracture Healing: Are Specific Deficiencies in Amino Acids Important in Nonunion Development?
Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Inverse relation of body weight with short-term and long-term mortality following hip fracture surgery: a meta-analysis.Journal of orthopaedic surgery and research · 2022Pooled it
- The Role of Diet in Osteoporotic Fracture Healing: a Systematic Review.Current osteoporosis reports · 2020Pooled it
- Fragility Fracture in a Young Man With Severe Depression, Malnutrition, and Reduced Mobility: A Case Report.Cureus · 2026Article
- Malnutrition drives re-revision and mortality in elderly revision arthroplasty: the prognostic value of GNRI.BMC musculoskeletal disorders · 2026Article
- Development and validation of a machine learning-based model for diagnosing perioperative malnutrition in older adults with hip fracture.Frontiers in nutrition · 2026Article
- Association between triglyceride glucose-body mass index and nonunion in older patients following limb fracture surgery: a multicenter retrospective cohort study.Frontiers in medicine · 2026Article
- Malnutrition in Older Hip Fracture Patients: Prevalence, Pathophysiology, Clinical Outcomes, and Treatment-A Systematic Review.Journal of clinical medicine · 2025Review
- Analysis of the impact of underlying diseases in the elderly on postoperative re-fractures after osteoporotic compression fractures.Journal of orthopaedic surgery and research · 2024Article
- Mass Spectrometry Reveals Molecular Effects of Citrulline Supplementation during Bone Fracture Healing in a Rat Model.Journal of the American Society for Mass Spectrometry · 2024Article
- Development and validation of a novel nomogram of 1-year mortality in the elderly with hip fracture: a study of the MIMIC-III database.BMJ open · 2023Article
- Treatment of Femoral Shaft Pseudarthrosis, Case Series and Medico-Legal Implications.Journal of clinical medicine · 2022Article
- Association of Body Mass Index with Long-Term All-Cause Mortality in Patients Who Had Undergone a Vertebroplasty for a Vertebral Compression Fracture.Journal of clinical medicine · 2022Article
- Effect of Dietary Amino Acids L-Arginine and Lysine on Implant Osseointegration.Journal of pharmacy & bioallied sciences · 2022Article
- Heat Stress Alters the Effect ofAnimals : an open access journal from MDPI · 2022Article
- Efficacy of adjuvant treatment for fracture nonunion/delayed union: a network meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2022Article
- The need for nutritional assessment and interventions based on the prognostic nutritional index for patients with femoral fractures: a retrospective study.Perioperative medicine (London, England) · 2021Article
- Bone Healing and Inflammation: Principles of Fracture and Repair.Seminars in plastic surgery · 2021Review
- Exogenous PTH 1-34 Attenuates Impaired Fracture Healing in Endogenous PTH Deficiency Mice via Activating Indian Hedgehog Signaling Pathway and Accelerating Endochondral Ossification.Frontiers in cell and developmental biology · 2021Article
- The biology and treatment of acute long-bones diaphyseal fractures: Overview of the current options for bone healing enhancement.Bone reports · 2020Review
- Allogenic Bone Graft Enriched by Periosteal Stem Cell and Growth Factors for Osteogenesis in Critical Size Bone Defect in Rabbit Model: Histopathological and Radiological Evaluation.Iranian journal of pathology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the increasing incidence of fractures now, and in the future, the absolute number of bone-healing complications such as nonunion development will also increase. Next to fracture-dependent factors such as large bone loss volumes and inadequate stabilization, the nutritional state of these patients is a major influential factor for the fracture repair process. In this review, we will focus on the influence of protein/amino acid malnutrition and its influence on fracture healing. Mainly, the arginine-citrulline-nitric oxide metabolism is of importance since it can affect fracture healing via several precursors of collagen formation, and through nitric oxide synthases it has influences on the bio-molecular inflammatory responses and the local capillary growth and circulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.