Evidence map›Paper›PMID 30384445›Full record

ArticleMolecules (Basel, Switzerland)2018

8e Protects against Acute Cerebral Ischemia by Inhibition of PI3Kγ-Mediated Superoxide Generation in Microglia.

Linna Wang, Xiaoli Wang, Tingting Li, Yihua Zhang, Hui Ji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Linna WangState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu, China. aprilwln@stu.cpu.edu.cn.
Xiaoli WangKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, Jiangsu, China. xiaoliwang@jiangnan.edu.cn.
Tingting LiState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu, China. lttcpu@cpu.edu.cn.
Yihua ZhangJiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, Jiangsu, China. zyhtgd@163.com.
Hui JiState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu, China. huiji@cpu.edu.cn.
China Pharmaceutical University · CNJiangnan University · CN

Funding

National Natural Science Foundation of China No.81872867, No.81503150, No.21502071Priority Academic Program Development of Jiangsu Higher Education Institutions and the Policy Directive Program of Jiangsu Province BY2015072-03
6 · The paper itself

Abstract

The inflammatory response mediated by microglia plays a critical role in the progression of ischemic stroke. Phosphoinositide 3-kinase gamma (PI3Kγ) has been implicated in multiple inflammatory and autoimmune diseases, making it a promising target for therapeutic intervention. The aim of this study was to evaluate the efficacy of

Indexed as

Phosphoinositide-3 Kinase InhibitorsAnimalsBenzofuransBrain IschemiaDisease Models, AnimalHumansHydrogen SulfideInfarction, Middle Cerebral ArteryMicrogliaNADPH Oxidase 2NeuronsNuclear ProteinsRatsRNA, Small InterferingSignal TransductionSoluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins3-n-butylphthalideBenzofuransCybb protein, ratHydrogen SulfideNADPH Oxidase 2Nsfl1c protein, ratNuclear ProteinsPhosphoinositide-3 Kinase InhibitorsRNA, Small InterferingSoluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinsSuperoxidescerebral ischemia/reperfusionhydrogen sulfidemicroglial activationNOX2PI3Kγ

Identifiers

PMID30384445
PMCPMC6278485
OpenAlexW2898634013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.