Trial reportJournal of acquired immune deficiency syndromes (1999)2019
HIV-Related Stigma, Motivation to Adhere to Antiretroviral Therapy, and Medication Adherence Among HIV-Positive Methadone-Maintained Patients.
Trial report in Journal of acquired immune deficiency syndromes (1999), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- HIV infection disclosure, treatment self-efficacy and quality of life in HIV-infected MSM receiving antiretroviral therapy.BMC infectious diseases · 2022Trial
- The burden of HIV-related stigma on clinical and quality of life outcomes: results from a systematic literature review.Health psychology and behavioral medicine · 2026Review
- Mpox Stigma During the 2022 Outbreak Among Men Who Have Sex With Men in the United States.Stigma and health · 2025Article
- The Association of HIV Criminalization Law and Disparities in Transplant Education among People with HIV.AIDS and behavior · 2025Article
- Stigmatization, Medication Adherence and Resilience Among Recently Diagnosed People Living With HIV/AIDS (PLWHA): A Mixed-Method Study.Public health challenges · 2025Article
- How Does Anticipated HIV Stigma Affect Medication Adherence? A Longitudinal Path Analysis Model.AIDS and behavior · 2024Article
- Personal Growth and Life Satisfaction during Fertility Treatment-A Comparison between Arab and Jewish Women.International journal of environmental research and public health · 2023Article
- Self-awareness as the key to successful adherence to antiretroviral therapy among people living with HIV in Indonesia: A grounded theory study.Belitung nursing journal · 2023Article
- Article
- Characterizing factors influencing adherence to surgery and chemotherapy amongst women suffering from breast cancer in Mbingo Baptist Hospital Cameroon.The Pan African medical journal · 2022Article
- Knowledge of Antiretroviral Treatment and Associated Factors in HIV-Infected Patients.Healthcare (Basel, Switzerland) · 2021Article
- Physical, Emotional, and Psychosocial Challenges Associated with Daily Dosing of HIV Medications and Their Impact on Indicators of Quality of Life: Findings from the Positive Perspectives Study.AIDS and behavior · 2021Article
- Prevalence and Determinants of Medication Adherence among Patients with HIV/AIDS in Southern Vietnam.Infectious disease reports · 2021Article
- An update on drug-drug interactions between antiretroviral therapies and drugs of abuse in HIV systems.Expert opinion on drug metabolism & toxicology · 2020Review
- Anticipated stigma and medication adherence among people living with HIV: the mechanistic roles of medication support and ART self-efficacy.AIDS care · 2020Article
- Syndemic factors associated with adherence to antiretroviral therapy among HIV-positive adult heterosexual men.AIDS research and therapy · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundOpioid agonist therapies with methadone are associated with higher levels of adherence to antiretroviral therapy (ART); yet, no studies have explored factors associated with optimal ART levels in HIV-positive patients on methadone maintenance treatment, including explanatory pathways using mediation analysis.
settingParticipants included 121 HIV-positive, methadone-maintained patients who reported HIV-risk behaviors and were taking ART.
methodsParticipants were assessed using an audio computer-assisted self-interview. Multivariable logistic regression was used to identify significant correlates and PROCESS macro to test the explanatory pathway (ie, mediational effect) for optimal ART adherence.
resultsAmong 121 participants, almost 40% reported suboptimal adherence to ART. Optimal ART adherence was significantly associated with being virally suppressed [adjusted odds ratio (aOR) = 6.470, P = 0.038], higher motivation to adhere to ART (aOR = 1.171, P = 0.011), and lower anticipated HIV-related stigma (aOR = 0.384, P = 0.015). Furthermore, results revealed an indirect effect of motivation on the relationship between HIV stigma and ART adherence (effect = -0.121, P = 0.043), thus supporting the mediation effect.
conclusionsOur findings underscore the complexities surrounding ART adherence, even in patients on methadone maintenance treatment. These findings provide insights on how to more effectively intervene to optimize HIV treatment outcomes, including HIV treatment-as-prevention initiatives, in methadone-maintained patients.
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