ArticleMolecular reproduction and development2019
Changes in the uterine metabolome of the cow during the first 7 days after estrus.
Article in Molecular reproduction and development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Metabolomic profiling of neat uterine luminal fluid in cows: local enrichment and nutritional modulation.The veterinary quarterly · 2026Article
- Metabolomic and transcriptomic landscape of the bovine uterine lumen during the second week of the estrous cycle.Journal of animal science and biotechnology · 2026Article
- Application of omics technologies to identify reproductive phenotypes in the context of assisted reproductive technologies for cattle.Animal reproduction · 2026Article
- Research progress on non-invasive testing of endometrial receptivity.Frontiers in reproductive health · 2026Review
- Urinary metabolite signatures as predictive biomarkers for estrus detection in water buffaloes: a proton-NMR based study.The veterinary quarterly · 2025Article
- Applications of metabolomics in cow health assessment.Metabolomics : Official journal of the Metabolomic Society · 2025Review
- Metabolomic changes of uterine fluid of lactating cows with subclinical endometritis and treated with docosahexaenoic acid (DHA).Veterinary and animal science · 2025Article
- Key biochemical pathways during pregnancy in livestock: mechanisms regulating uterine and placental development and function.Reproduction & fertility · 2025Review
- Feeding rumen-protected choline during the periconceptional period programs postnatal phenotype of suckled beef calves.Journal of animal science and biotechnology · 2025Article
- A low concentration of choline chloride alters the developmental program of the bovine preimplantation embryo.Reproduction & fertility · 2024Article
- Article
- Genome wide identification and characterization of fertility associated novel CircRNAs as ceRNA reveal their regulatory roles in sheep fecundity.Journal of ovarian research · 2023Article
- Maternal contributions to pregnancy success: from gamete quality to uterine environment.Animal reproduction · 2023Article
- Identification of photoperiod-induced specific miRNAs in the adrenal glands of Sunite sheep (Frontiers in veterinary science · 2022Article
- The embryo culture media in the era of epigenetics: is it time to go back to nature?Animal reproduction · 2022Review
- Choline acts during preimplantation development of the bovine embryo to program postnatal growth and alter muscle DNA methylation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- The Metabolic Signature of In Vitro Produced Bovine Embryos Helps Predict Pregnancy and Birth after Embryo Transfer.Metabolites · 2021Article
- Metabolomic profiles of plasma and uterine luminal fluids from healthy and repeat breeder Holstein cows.BMC veterinary research · 2021Article
- Chemotactic behavior ofAnimal reproduction · 2021Article
- Genes associated with survival of female bovine blastocysts produced in vivo.Cell and tissue research · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The uterine microenvironment during the first 7 days after ovulation accommodates and facilitates sperm transit to the oviduct and constitutes the sole source of nutrients required for the development of preimplantation embryos. Knowledge of the composition of uterine fluid is largely incomplete. Using untargeted mass spectrometry, we characterized the uterine metabolome during the first 7 days of the estrous cycle. Bovine uteri were collected on Days 0 (N = 4), 3 ( N = 4), 5 ( N = 3), and 7 ( N = 4) relative to ovulation and flushed with Dulbecco's phosphate-buffered saline. A total of 1,993 molecular features were detected of which 184 peaks with putative identification represent 147 unique metabolites, including amino acids, benzoic acids, lipid molecules, carbohydrates, purines, pyrimidines, vitamins, and other intermediate and secondary metabolites. Results revealed changes in the uterine metabolome as the cow transitions from ovulation to Day 7 of the estrous cycle. The majority of metabolites that changed with day reached maximum intensity on either Day 5 or 7 relative to ovulation. Moreover, several metabolites found in the uterine fluid have signaling capabilities and some have been shown to affect preimplantation embryonic development. In conclusion, the metabolome of the bovine uterus changes during early stages of the estrous cycle and is likely to participate in the regulation of preimplantation embryonic development. Data reported here will serve as the basis for future studies aiming to evaluate maternal regulation of preimplantation embryonic development and optimal conditions for the culture of embryos.
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Registered trials
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