ArticleThe Journal of clinical endocrinology and metabolism2019
Amygdalar Metabolic Activity Independently Associates With Progression of Visceral Adiposity.
Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Obesity-related differences in amygdala and hippocampal volume and metabolism before and after a placebo-controlled antidepressant trial in major depressive disorder.Scientific reports · 2026Trial
- Imaging Findings Associated With Socioenvironmental Exposures Inform Mechanisms of Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Age modulates the link between stress-related neural activity and mortality.Nature communications · 2025Article
- Epilepsy-heart syndrome: Back to the future!Epilepsia · 2025Article
- Radionuclide Imaging of Heart-Brain Connections.Heart failure clinics · 2025Review
- Heart-brain axis: Pushing the boundaries of cardiovascular molecular imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024Review
- Imaging of the brain-heart axis: prognostic value in a European setting.European heart journal · 2024Article
- Health position paper and redox perspectives - Disease burden by transportation noise.Redox biology · 2024Review
- Mind the Heart: Stress-Associated Neural Activity Associates With Perivascular Coronary Inflammation and Vulnerable Plaque Features.JACC. Cardiovascular imaging · 2023Article
- Radionuclide Imaging of Heart-Brain Connections.Cardiology clinics · 2023Review
- Gender medicine: effects of sex and gender on cardiovascular disease manifestation and outcomes.Nature reviews. Cardiology · 2023Review
- Heart-brain interactions in cardiac and brain diseases: why sex matters.European heart journal · 2022Review
- Chronic physical exercise alleviates stress-associated amygdala metabolic activity in obese women: A prospective serialFrontiers in endocrinology · 2022Article
- Integrating multiple brain imaging modalities does not boost prediction of subclinical atherosclerosis in midlife adults.NeuroImage. Clinical · 2022Article
- A neurobiological link between transportation noise exposure and metabolic disease in humans.Psychoneuroendocrinology · 2021Article
- The brain connection between stress and heart: a convincing research opportunity to reduce risk and gender disparity in cardiovascular disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Affective brain patterns as multivariate neural correlates of cardiovascular disease risk.Social cognitive and affective neuroscience · 2020Article
- The fear-defense system, emotions, and oxidative stress.Redox biology · 2020Review
- Frontostriatal Brain Activation Is Associated With the Longitudinal Progression of Cardiometabolic Risk.Psychosomatic medicine · 2020Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
contextEpidemiologic data link psychological stress to adiposity. The underlying mechanisms remain uncertain.
objectivesTo test whether (i) higher activity of the amygdala, a neural center involved in the response to stress, associates with greater visceral adipose tissue (VAT) volumes and (ii) this association is mediated by increased bone marrow activity.
settingMassachusetts General Hospital, Boston, Massachusetts. PATIENTS: Two hundred forty-six patients without active oncologic, cardiovascular, or inflammatory disease who underwent clinical 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging were studied. VAT imaging was repeated ∼1 year later in 68 subjects.
designMetabolic activity of the amygdala (AmygA), hematopoietic tissue activity, and adiposity volumes were measured with validated methods.
main outcome measureThe relationship between AmygA and baseline and follow-up VAT.
resultsAmygA associated with baseline body mass index (standardized β = 0.15; P = 0.01), VAT (0.19; P = 0.002), and VAT/subcutaneous adipose tissue ratio (0.20; P = 0.002), all remaining significant after adjustment for age and sex. AmygA also associated with bone marrow activity (0.15; P = 0.01), which in turn associated with VAT (0.34; P < 0.001). Furthermore, path analysis showed that 48% of the relationship between AmygA and baseline VAT was mediated by increased bone marrow activity (P = 0.007). Moreover, AmygA associated with achieved VAT after 1 year (P = 0.02) after adjusting for age, sex, and baseline VAT.
conclusionsThese results suggest a neurobiological pathway involving the amygdala and bone marrow linking psychosocial stress to adiposity in humans. Future studies should test whether targeting this mechanism attenuates adiposity and its complications.
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