Evidence map›Paper›PMID 30383224›Full record

ArticleInternational health2019

Towards the third 90: improving viral load testing with a simple quality improvement program in health facilities in Malawi.

Julie Hubbard, Gift Kakwesa, Mike Nyirenda, James Mwambene, Ashley Bardon, Kelvin Balakasi, Kathryn Dovel, Thokozani Kalua, Risa M Hoffman

Open access · bronzeAbstract read
In one paragraph

Article in International health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Dried Blood Spots to Assess Cardiovascular-Kidney-Metabolic Health.Journal of the American Heart Association · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Julie HubbardDepartment of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at the University of California Los Angeles, 10833 Le Conte Avenue, 37-121 CHS, Los Angeles, CA, USA.
Gift KakwesaPartners in Hope/EQUIP.
Mike NyirendaPartners in Hope/EQUIP.
James MwambenePartners in Hope/EQUIP.
Ashley BardonDepartment of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at the University of California Los Angeles, 10833 Le Conte Avenue, 37-121 CHS, Los Angeles, CA, USA.
Kelvin BalakasiPartners in Hope/EQUIP.
Kathryn DovelDepartment of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at the University of California Los Angeles, 10833 Le Conte Avenue, 37-121 CHS, Los Angeles, CA, USA.
Thokozani KaluaMinistry of Health, Department of HIV and AIDS, Area 3, Lilongwe, Malawi.
Risa M HoffmanDepartment of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at the University of California Los Angeles, 10833 Le Conte Avenue, 37-121 CHS, Los Angeles, CA, USA.
Partners In Health · USUniversity of California, Los Angeles · USMinistry of Health · MW

Funding

Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A · 1991 to 2018
$39.9M
NIAID NIH HHS L30 AI075486NIAID NIH HHS P30 AI028697PEPFAR AID-OAA-A-15-00070
6 · The paper itself

Abstract

backgroundViral load (VL) scale-up efforts have largely focused on laboratory systems, with less attention on facility-level strengthening of staff who facilitate VL testing. To address this gap we implemented a quality improvement (QI) program at 13 health facilities in central and southern Malawi.

methodsQI program tools focused on patient and provider VL knowledge and clarification of site-level roles and responsibilities, including the designation of a VL 'focal person' to oversee all VL activities. T-tests were used to compare differences in VL testing before (November 2016-April 2017) and after (May 2017-November 2017) the intervention.

resultsThe mean number of VL tests performed significantly increased after implementation of the QI program. Overall there was a 164% increase in the mean number of routine VL tests performed per month (p<0.001). Increased VL testing was sustained during the 6 months of follow-up.

conclusionsA simple QI program focused on improving VL knowledge among patients and providers, and clarifying staff roles at a facility level increased VL testing over a 6-month period. Further investigation is needed on whether this program can be scaled in different settings across sub-Saharan Africa and on the duration of follow-up required for sustained improvements in VL testing.

Indexed as

Health FacilitiesQuality ImprovementAdolescentAdultFemaleHIV InfectionsHumansMalawiMaleProgram EvaluationViral Loadhealth servicesHIV infectionsMalawimentorsquality improvementviral load

Identifiers

PMID30383224
PMCPMC6676971
OpenAlexW2898889749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.