ArticleJournal of speech, language, and hearing research : JSLHR2018
Minimally Detectable Change and Minimal Clinically Important Difference of a Decline in Sentence Intelligibility and Speaking Rate for Individuals With Amyotrophic Lateral Sclerosis.
Article in Journal of speech, language, and hearing research : JSLHR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07173049 (Speech Supplementation Strategies for Improving Intelligibility in Children With Cerebral Palsy), which is not on this map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Speech Supplementation Strategies for Improving Intelligibility in Children With Cerebral Palsy (CP)
Who cites it
55 citing papers in PubMed, 77 citations in OpenAlex.
- Study 19 (MCI186-19) Post Hoc Analyses.Muscle & nerve · 2026Trial
- Improving Perceptual Speech Ratings: The Effects of Auditory Training on Judgments of Dysarthric Speech.Journal of speech, language, and hearing research : JSLHR · 2023Trial
- Effects of a Single Electrical Stimulation Session on Foot Force Production, Foot Dome Stability, and Dynamic Postural Control.Journal of athletic training · 2023Trial
- Dissociable Effects of Dysarthria Etiology and Severity on the Minimally Detectable Change of Speech Intelligibility.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Speech-based digital endpoints track ALS progression and align with standard clinical outcomes: evidence from the VRG50635 trial.Scientific reports · 2026Article
- Towards Metabolomics-Guided Healthy and Anti-Aging Nutrition.Metabolites · 2026Article
- Variable Speech Cueing Effects in Talkers With Parkinson's Disease.American journal of speech-language pathology · 2026Article
- Short prescribed exercises can quantify upper limb functioning in neurodegenerative disease.Journal of neuroengineering and rehabilitation · 2026Article
- Analytical and clinical validation of step counting method in people living with amyotrophic lateral sclerosis.Scientific reports · 2025Article
- Exploring Methodological Decisions for Calculating the Minimally Detectable Change in Dysarthria: Reliability, Statistics, and Standard Error of Measurement.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Progress Toward Estimating the Minimal Clinically Important Difference of Intelligibility: A Crowdsourced Perceptual Experiment.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Automated Scoring of the Speech Intelligibility Test Using Autoscore.American journal of speech-language pathology · 2025Article
- Minimal Detectable Change of Experienced and Novice Listeners' Ratings of Overall Severity of Voice Quality in Adductor Laryngeal Dystonia.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Development of the physical activity counseling practices scale in health professionals: a validity and reliability study.BMC primary care · 2025Article
- Free-living monitoring of ALS progression in upper limbs using wearable accelerometers.Journal of neuroengineering and rehabilitation · 2024Observational
- Progression of Motor Speech Function in Speakers With Primary Progressive Apraxia of Speech.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Operationalizing Clinical Speech Analytics: Moving From Features to Measures for Real-World Clinical Impact.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Automated speech analytics in ALS: higher sensitivity of digital articulatory precision over the ALSFRS-R.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2024Article
- Multimodal speech biomarkers for remote monitoring of ALS disease progression.Computers in biology and medicine · 2024Article
- Multimodal Speech Biomarkers for Remote Monitoring of ALS Disease Progression.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Purpose: The purpose of this study was to determine the minimally detectable change (MDC) and minimal clinically important difference (MCID) of a decline in speech sentence intelligibility and speaking rate for individuals with amyotrophic lateral sclerosis (ALS). We also examined how the MDC and MCID vary across severities of dysarthria. Method: One-hundred forty-seven patients with ALS and 49 healthy control subjects were selected from a larger, longitudinal study of bulbar decline in ALS, resulting in a total of 650 observations. Intelligibility and speaking rate in words per minute (WPM) were calculated using the Sentence Intelligibility Test (Yorkston, Beukelman, & Hakel, 2007), and the ALS Functional Rating Scale-Revised (Cedarbaum et al., 1999) was administered to capture patient perception of motor impairment. The MDC at the 95% confidence level was estimated using the following formula: MDC95 = 1.96 × √2 × SEM. For estimation of the MCID, receiver operating characteristic curves were generated, and area under the curve and optimal thresholds to maximize sensitivity and specificity were calculated. Results: The MDC for sentence intelligibility was 12.07%, and the MCID was 1.43%. The MDC for speaking rate was 36.57 WPM, and the MCID was 8.80 WPM. Both MDC and MCID estimates varied with severity of dysarthria. Conclusions: The findings suggest that declines greater than 12% sentence intelligibility and 37 WPM are required to be outside measurement error and that these estimates vary widely across dysarthria severities. The MDC and MCID metrics used in this study to detect real and clinically relevant change should be estimated for other measures of speech outcomes in intervention research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.