ArticlePLoS biology2018
Spatiotemporal coordination of cell division and growth during organ morphogenesis.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- A multiscale growth atlas of Arabidopsis: linking cell dynamics to organ development.The New phytologist · 2026Pooled it
- Growth-rate coordination across the width of a leaf preserves its flatness.PLoS biology · 2026Article
- Brassinosteroid controls leaf air space patterning non-cell autonomously by promoting epidermal growth.Development (Cambridge, England) · 2026Article
- A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales.eLife · 2026Article
- Growth history leaves a geometric trace in puzzle cells.EMBO reports · 2026Article
- Morphogenesis of moss leaf-like organs through variations in deeply shared developmental principles.Science advances · 2026Article
- Biregionally differentiated growth generates sharp apex and concave joints in leaves.The Plant journal : for cell and molecular biology · 2025Article
- Multi-scale dynamics influence the division potential of stomatal lineage ground cells in Arabidopsis.Nature communications · 2025Article
- Rearranging development makes a slippery slope: a commentary on 'Carnivorous Nepenthes pitcher plants combine common developmental processes to make a complex epidermal trapping surface'.Annals of botany · 2025Article
- Carnivorous Nepenthes pitcher plants combine common developmental processes to make a complex epidermal trapping surface.Annals of botany · 2025Article
- Modulation of cell differentiation and growth underlies the shift from bud protection to light capture in cauline leaves.Plant physiology · 2024Article
- Conserved physical mechanisms of cell and tissue elongation.Development (Cambridge, England) · 2024Review
- Identification of Chromosomal Regions and Candidate Genes forPlants (Basel, Switzerland) · 2024Article
- Developmental timing in plants.Nature communications · 2024Review
- Precocious cell differentiation occurs in proliferating cells in leaf primordia in ArabidopsisFrontiers in plant science · 2024Article
- Anisotropic cell growth at the leaf base promotes age-related changes in leaf shape in Arabidopsis thaliana.The Plant cell · 2023Article
- An optimized pipeline for live imaging whole Arabidopsis leaves at cellular resolution.Plant methods · 2023Article
- Model-based reconstruction of whole organ growth dynamics reveals invariant patterns in leaf morphogenesis.Quantitative plant biology · 2023Article
- Live-imaging provides an atlas of cellular growth dynamics in the stamen.Plant physiology · 2022Article
- Using quantitative methods to understand leaf epidermal development.Quantitative plant biology · 2022Review
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
A developing plant organ exhibits complex spatiotemporal patterns of growth, cell division, cell size, cell shape, and organ shape. Explaining these patterns presents a challenge because of their dynamics and cross-correlations, which can make it difficult to disentangle causes from effects. To address these problems, we used live imaging to determine the spatiotemporal patterns of leaf growth and division in different genetic and tissue contexts. In the simplifying background of the speechless (spch) mutant, which lacks stomatal lineages, the epidermal cell layer exhibits defined patterns of division, cell size, cell shape, and growth along the proximodistal and mediolateral axes. The patterns and correlations are distinctive from those observed in the connected subepidermal layer and also different from the epidermal layer of wild type. Through computational modelling we show that the results can be accounted for by a dual control model in which spatiotemporal control operates on both growth and cell division, with cross-connections between them. The interactions between resulting growth and division patterns lead to a dynamic distributions of cell sizes and shapes within a deforming leaf. By modulating parameters of the model, we illustrate how phenotypes with correlated changes in cell size, cell number, and organ size may be generated. The model thus provides an integrated view of growth and division that can act as a framework for further experimental study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.