Evidence map›Paper›PMID 30382943›Full record

ArticleThe Journal of clinical investigation2018

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer.

Daniel Nava Rodrigues, Pasquale Rescigno, David Liu, Wei Yuan, Suzanne Carreira, Maryou B Lambros, George Seed, Joaquin Mateo, Ruth Riisnaes, Stephanie Mullane and 42 more

Registry-linked trialAbstract readPublished Erratum
In one paragraph

Article in The Journal of clinical investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06056791 (An Open-label, Phase I/IIa Dose Escalation and Expansion Study to Determine the Safety and Clinical Activity of an Immune Priming Cell Therapy), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06056791 phase1 / phase2completednot on this mapstarted 2023, after this paper: background citation

An Open-label, Phase I/IIa Dose Escalation and Expansion Study to Determine the Safety and Clinical Activity of an Immune Priming Cell Therapy (INKmune) in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)

TypeinterventionalSponsorInmune Bio, Inc.Ran2023 to 2025Enrolled12ConditionsCancer, Metastatic Castration-resistant Prostate Cancer, mCRPCArmsINKmune
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020
    Pooled it
  2. Pembrolizumab for Treatment-Refractory Metastatic Castration-Resistant Prostate Cancer: Multicohort, Open-Label Phase II KEYNOTE-199 Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020
    Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Therapeutic Implications for Intrinsic Phenotype Classification of Metastatic Castration-Resistant Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  10. Article
  11. Review
  12. Hypermutation, Mismatch Repair Deficiency, and Defining Predictors of Response to Checkpoint Blockade.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. CD38 in Advanced Prostate Cancers.European urology · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

52 authors.

Daniel Nava Rodrigues
Pasquale Rescigno
David Liu
Wei Yuan
Suzanne Carreira
Maryou B Lambros
George Seed
Joaquin Mateo
Ruth Riisnaes
Stephanie Mullane
Claire Margolis
Diana Miao
Susana Miranda
David Dolling
Matthew Clarke
Claudia Bertan
Mateus Crespo
Gunther Boysen
Ana Ferreira
Adam Sharp
Ines Figueiredo
Daniel Keliher
Saud Aldubayan
Kelly P Burke
Semini Sumanasuriya
Mariane Sousa Fontes
Diletta Bianchini
Zafeiris Zafeiriou
Larissa Sena Teixeira Mendes
Kent Mouw
Michael T Schweizer
Colin C Pritchard
Stephen Salipante
Mary-Ellen Taplin
Himisha Beltran
Mark A Rubin
Marcin Cieslik
Dan Robinson
Elizabeth Heath
Nikolaus Schultz
Joshua Armenia
Wassim Abida
Howard Scher
Christopher Lord
Alan D'Andrea
Charles L Sawyers
Arul M Chinnaiyan
Andrea Alimonti
Peter S Nelson
Charles G Drake
Eliezer M Van Allen
Johann S de Bono

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Tumor and Circulating Markers as Links Between Obesity and Lethal Prostate CanceP50CA090381 · NCI · DANA-FARBER CANCER INSTITUTE · PI LODA, MASSIMO · 2002 to 2017
$36.2M
The MSKCC-UW/Fred Hutch Prostate Cancer Drug Resistance and Sensitivity CenterU54CA224079 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SAWYERS, CHARLES L. · 2017 to 2021
$6.8M
Understanding Resistance to Next Generation AntiandrogensR01CA155169 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SAWYERS, CHARLES L. · 2012 to 2022
$3.8M
Medical Research Council MR/M018318/1NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA090381NCI NIH HHS R01 CA155169NCI NIH HHS U54 CA224079
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID30382943
PMCPMC6205373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.