ArticleBiomedical engineering online2018
An imaging system integrating optical coherence tomography and interferometry for in vivo measurement of the thickness and dynamics of the tear film.
Article in Biomedical engineering online, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Silicone hydrogel versus hydrogel soft contact lenses for differences in patient-reported eye comfort and safety.The Cochrane database of systematic reviews · 2023Pooled it
- Imaging Approaches for the Diagnosis of Dry Eye: A Review.Diagnostics (Basel, Switzerland) · 2026Review
- Layer-by-layer tear film measurement in patients with dry eye and meibomian gland dysfunction.International journal of ophthalmology · 2025Article
- Characterization of the Pre-lens Tear Film in Hydrogel and Silicone Hydrogel Contact Lens Wear.Journal of ophthalmic & vision research · 2025Article
- Subjective Grading and Objective Assessment After Switching to a Daily Disposable Silicone Hydrogel Contact Lens.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Contact lens fitting and changes in the tear film dynamics: mathematical and computational models review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Review
- Association between Dry Eye Parameters Depends on Tear Components.Journal of clinical medicine · 2022Article
- Human meibum and tear film derived cholesteryl and wax esters in meibomian gland dysfunction and tear film structure.The ocular surface · 2022Article
- Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease.Investigative ophthalmology & visual science · 2021Article
- Human precorneal tear film and lipid layer dynamics in meibomian gland dysfunction.The ocular surface · 2021Article
- Novel Approaches for Imaging-Based Diagnosis of Ocular Surface Disease.Diagnostics (Basel, Switzerland) · 2020Review
- Objective Imaging Diagnostics for Dry Eye Disease.Journal of ophthalmology · 2020Review
- Automatic assessment of tear film and tear meniscus parameters in healthy subjects using ultrahigh-resolution optical coherence tomography.Biomedical optics express · 2019Article
- In vivo thickness measurement of the lipid layer and the overall tear film by interferometry.Optics letters · 2019Article
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5 authors.
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Abstract
backgroundThe outermost layer of the tear film consists of a thin lipid layer (LL). The lipid layer serves as a barrier against evaporation of the aqueous component of the tear film. The ability to simultaneously image both the lipid layer thickness and overall tear film thickness is novel, and will help further understandings of mechanisms of how the lipid layer assembles and interacts with the full tear film thickness.
methodsWe developed a system that combines simultaneous optical coherence tomography (OCT) and thickness dependent fringes (TDF) interferometry for in vivo imaging of the tear film. The OCT possesses an axial resolution of 1.38 µm in tear film, providing an accurate measurement of the thickness of the overall tear film. The TDF can detect a minimal change of approximately 15 nm in LL thickness. In addition, the spatial resolution of TDF images in x-y plane is 5 µm.
resultsThe effect of instilling artificial tears on the PCTF and PLTF was examined. In both contact lens and non-contact lens wear, it could be observed from the OCT results that instillation of artificial tears increased the thickness of the overall tear film immediately, followed by a gradual reduction thereafter. These findings were consistent with other studies. However, unlike those previous reports, the thickness of the LL in this study was quantified simultaneously with the TDF subsystem. The results showed that bulking agents such as these artificial tears were not necessarily intended to increase the LL thickness. Immediately after instillation of artificial tears, the PCTF increased from 4.4 ± 0.97 to 20.3 ± 3.6 µm. The PCTF then decreased to 8.8 ± 2.1 µm at 4 min post-instillation. The thicknesses of the LL were 62.4 ± 14.5 nm, 48.7 ± 5.3 nm, and 55.2 ± 9.8 nm at pre-drop instillation, post-drop instillation, and 4-min post-drop instillation, respectively.
conclusionsIn this work, we have described a novel imaging system that integrated OCT and TDF imaging techniques, which may facilitate the study of many physiological and clinical aspects of the tear film.
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