Evidence map›Paper›PMID 30382841›Full record

ArticleBMC genomics2018

Improved Macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues.

Tao Tan, Lin Xia, Kailing Tu, Jie Tang, Senlin Yin, Lunzhi Dai, Peng Lei, Biao Dong, Hongbo Hu, Yong Fan and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Tao TanDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Lin XiaState Key Laboratory of Biotherapy & Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Kailing TuState Key Laboratory of Biotherapy & Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Jie TangState Key Laboratory of Biotherapy & Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Senlin YinState Key Laboratory of Biotherapy & Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Lunzhi DaiState Key Laboratory of Biotherapy & Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Peng LeiState Key Laboratory of Biotherapy & Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Biao DongState Key Laboratory of Biotherapy & Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Hongbo HuState Key Laboratory of Biotherapy & Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yong FanKey Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yang YuDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. yuyang5012@hotmail.com.
Dan XieState Key Laboratory of Biotherapy & Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China. danxie@scu.edu.cn.
State Key Laboratory of BiotherapyPeking University Third Hospital · CNSichuan University · CNGuangzhou Medical University · CNWest China Hospital of Sichuan University · CNWest China Medical Center of Sichuan University · CN

Funding

National Natural Science Foundation of China 31571327National Natural Science Foundation of China 31771426National Natural Science Foundation of China 81570060National Natural Science Foundation of China 91631111National Natural Science Foundation of China 91740111the National Key Research and Development Program 2016YFA0502203the National Key Research and Development Program 2017YFC0840100
6 · The paper itself

Abstract

backgroundsMacaca fascicularis (M. fascicularis) is a primate model organism that played important role in studying human health. It is vital to better understand the similarity and differences of gene regulation between M. fascicularis and human. Current comparative study of gene regulation between the two species are limited by low quality of gene annotation and lack of regulatory element data on M. fascicularis genome.

resultsIn this study, we improved the M. fascicularis gene annotation with 57 gene expression data from multiple tissues and, more importantly, a manual curation procedure. The new annotation enabled us to map gene expression and identify gene location more accurately.

conclusionsComparing with human gene expression data from the same cell types, we characterized the evolution of expression patterns of homologous genes.

Indexed as

Computational BiologyEvolution, MolecularMolecular Sequence AnnotationTranscriptomeAnimalsGene Expression ProfilingHumansMacaca fascicularisReproducibility of ResultsWorkflowCrab-eating macaqueEvolutionGene regulation

Identifiers

PMID30382841
PMCPMC6211470
OpenAlexW2898857789

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.