ArticleBMC genomics2018
Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus).
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Single-step genome-wide association study for carcass quality traits in Angus beef cattle.Tropical animal health and production · 2025Article
- Genomic insights into Yanbian cattle: Breed-specific selective sweeps identified by whole-genome sequencing.PloS one · 2025Article
- Identification of Heilongjiang crossbred beef cattle pedigrees and reveals functional genes related to economic traits based on whole-genome SNP data.Frontiers in genetics · 2024Article
- Article
- Selection signatures in two oldest Russian native cattle breeds revealed using high-density single nucleotide polymorphism analysis.PloS one · 2020Article
- The Molecular Characteristics of theGenes · 2019Article
- Genomic Patterns of Homozygosity in Chinese Local Cattle.Scientific reports · 2019Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
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Abstract
backgroundThe aim of this study was to analyze potential influences of polymorphisms within the regulatory region of the bovine SIRT6 gene on carcass quality traits. Expression analyses suggested that SIRT6 gene is predominately expressed in kidney, compared with other tissues. In 535 indigenous Chinese beef cattle, two novel single nucleotide polymorphisms (SNPs) were identified within the promoter region of the SIRT6 gene.
resultsAssociation analysis indicated that G allele of the c.-1100 A > G had a positive effect on fat deposition, and the Hap4/4 diplotype had more favourable results than other dipoltypes with respect to the evaluation of carcass quality traits. Furthermore, promoter activity associated with the Hap3 haplotype was measured at higher levels than the Hap1 haplotype, which would be in agreement with the previously described association analysis.
conclusionThe SIRT6 promoter variants significantly affect transcriptional levels and subsequently significantly influence bovine intramscular fat content.
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