ArticleBMC genomics2018
Evidence of peripheral olfactory impairment in the domestic silkworms: insight from the comparative transcriptome and population genetics.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Silencing Attempts ofInsects · 2026Article
- Functional Characterization of an Odorant Receptor Expressed in Newly Hatched Larvae of Fall ArmywormInsects · 2024Article
- Females smell differently: characteristics and significance of the most common olfactory sensilla of female silkmoths.Proceedings. Biological sciences · 2024Article
- Structure of an antennally-expressed carboxylesterase suggests lepidopteran odorant degrading enzymes are broadly tuned.Current research in insect science · 2023Article
- Stage-specific expression of an odorant receptor underlies olfactory behavioral plasticity in Spodoptera littoralis larvae.BMC biology · 2021Article
- Article
- Molecular Profiling of theG3 (Bethesda, Md.) · 2019Article
- Candidate chemosensory genes identified from the greater wax moth, Galleria mellonella, through a transcriptomic analysis.Scientific reports · 2019Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe insect olfactory system is a highly specific and sensitive chemical detector, which plays important roles in feeding, mating and finding an appropriate oviposition site. The ecological niche of Bombyx mori has changed greatly since domestication from B. mandarina, and its olfactory response to environmental odorants clearly decreased. However, the mechanisms that result in the olfactory impairment are largely unknown.
resultsThe antennal transcriptomes were compared between the domestic and wild silkworms. Comparison of the same sex between the domestic and wild silkworms revealed 1410 and 1173 differentially expressed genes (DEGs) in males and females, respectively. To understand the olfactory impairment, we mainly focused on the olfactory-related genes. In total, 30 olfactory genes and 19 odorant-degrading enzymes (ODEs) showed differential expression in the two comparisons, in which 19 and 14 were down-regulated in the domestic silkworm, respectively. Based on population genomic data, the down-regulated odorant receptors (ORs) showed a higher ratio of unique non-synonymous polymorphisms to synonymous polymorphisms (N/S ratio) in the domestic populations than that in the wild silkworms. Furthermore, one deleterious mutation was found in OR30 of the domestic population, which was located in transmembrane helix 6 (TM6).
conclusionsOur results suggested that down-regulation of the olfactory-related genes and relaxed selection might be the major reasons for olfactory impairment of the domestic silkworm reared completely indoor environment. Reversely, wild silkworm may increase expression and remove deleterious polymorphisms of olfactory-related genes to retain sensitive olfaction.
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