Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2019
Nutritional supplementation boosts aerobic exercise effects on functional brain systems.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The Effectiveness of Dance Interventions on Psychological and Cognitive Health Outcomes Compared with Other Forms of Physical Activity: A Systematic Review with Meta-analysis.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Chronic effects of different exercise types on brain activity in healthy older adults and those with Parkinson's disease: A systematic review.Frontiers in physiology · 2022Pooled it
- Multi-domain interventions for the prevention of dementia and cognitive decline.The Cochrane database of systematic reviews · 2021Pooled it
- Sensor-measured sedentariness and physical activity are differentially related to fluid and crystallized abilities in aging.Psychology and aging · 2020Trial
- Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.Journal of Alzheimer's disease : JAD · 2020Trial
- Brain resting state functional connectivity changes with aerobic exercise, and mindfulness: A narrative review.Sports medicine and health science · 2026Review
- Article
- Identify the direct and indirect impacts of the community built environment on the health of older adults.Frontiers in public health · 2025Article
- The effort hypothesis at the heart of the virtuous circle.EXCLI journal · 2025Review
- Bibliometric study of scientific productivity in intervention programs that improve cognitive impairment in older adults.European journal of translational myology · 2024Article
- Move Your Body, Boost Your Brain: The Positive Impact of Physical Activity on Cognition across All Age Groups.Biomedicines · 2023Review
- Symmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter.Frontiers in neurology · 2023Article
- Large-Scale Network Connectivity and Cognitive Function Changes After Exercise Training in Older Adults with Intact Cognition and Mild Cognitive Impairment.Journal of Alzheimer's disease reports · 2023Article
- Getting Fit to Counteract Cognitive Aging: Evidence and Future Directions.Physiology (Bethesda, Md.) · 2022Review
- Subjective Well-Being and Bilateral Anterior Insula Functional Connectivity After Exercise Intervention in Older Adults With Mild Cognitive Impairment.Frontiers in neuroscience · 2022Article
- Brain-based mechanisms of late-life depression: Implications for novel interventions.Seminars in cell & developmental biology · 2021Review
- The Impact of the BAILAMOS™ Dance Program on Brain Functional Connectivity and Cognition in Older Latino Adults: A Pilot Study.Journal of cognitive enhancement : towards the integration of theory and practice · 2021Article
- Exercise-Based Interventions for Internet Addiction: Neurobiological and Neuropsychological Evidence.Frontiers in psychology · 2020Review
- Occupational Physical Stress Is Negatively Associated With Hippocampal Volume and Memory in Older Adults.Frontiers in human neuroscience · 2020Article
- Acute Effects of a Multi-Ingredient Pre-Workout Supplement On 5-KM Running Performance in Recreationally-Trained Athletes.International journal of exercise science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
There is growing evidence that aerobic exercise protects against age-related cognitive decline and that cardiorespiratory fitness is an important factor for these benefits. Studies also suggest that combining physical activity with cognitive enrichment is beneficial. We further examine these predictions by comparing effects of a nutritional supplement promoting exercise capacity to a lower-intensity activity with cognitive enrichment on functional network and cognitive outcomes that otherwise decline with aging. Inactive healthy older adults were randomized to one of four groups including a low-intensity activity with complex cognitive demands (dancing), walking, walking+supplement, or an active control. Results showed that walking+supplement increased salience network functional connectivity (FC), with less training benefit for default mode network FC. Although cognitive performance did not increase for any training group, participants in the walking+supplement group who were on medication that boosted key neurotransmitters (e.g., selective serotonin reuptake inhibitors) showed improved processing speed. Overall, this study provides new insight into how to boost the protective effects of exercise on brain systems that otherwise deteriorate with aging. NEW & NOTEWORTHY Aerobic exercise effects on brain networks that otherwise decline with aging can be boosted with a nutritional supplement including beta-alanine. Beta-alanine supplementation could enhance the extent to which aerobic adaptations benefit the brain. In contrast, cognitive enrichment with low-intensity physical activity through dance did not affect functional networks. Medications that modulate neurotransmitters affected by aging (e.g., selective serotonin reuptake inhibitors) may modify effects of exercise on cognition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.