Evidence map›Paper›PMID 30382766›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

MicroRNA-30a as a candidate underlying sex-specific differences in neonatal hyperoxic lung injury: implications for BPD.

Yuhao Zhang, Cristian Coarfa, Xiaoyu Dong, Weiwu Jiang, Brielle Hayward-Piatkovskyi, Jason P Gleghorn, Krithika Lingappan

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 54 citations in OpenAlex.

  1. Sex Differences in Lung Immunity.Immunological reviews · 2026
    Review
  2. Sex, hormones, and lung health.Physiological reviews · 2026
    Review
  3. Article
  4. Article
  5. Therapeutic nanoparticle safety in pregnancy: Bridging knowledge gaps with environmental insights and a translational roadmap.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  12. Review
  13. Article
  14. Sex-related external factors influence pulmonary vascular angiogenesis in a sex-dependent manner.American journal of physiology. Heart and circulatory physiology · 2023
    Article
  15. Article
  16. Remarkable sex-specific differences at single-cell resolution in neonatal hyperoxic lung injury.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yuhao ZhangDepartment of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine , Houston, Texas.
Cristian CoarfaAdvanced Technology Cores, Baylor College of Medicine , Houston, Texas.
Xiaoyu DongDepartment of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine , Houston, Texas.
Weiwu JiangDepartment of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine , Houston, Texas.
Brielle Hayward-PiatkovskyiDepartment of Biological Sciences, University of Delaware , Newark, Delaware.
Jason P GleghornDepartment of Biological Sciences, University of Delaware , Newark, Delaware.
Krithika LingappanDepartment of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine , Houston, Texas.
Baylor College of Medicine · USTexas Children's Hospital · USUniversity of Delaware · US

Funding

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAININGT32GM008550 · NIGMS · UNIVERSITY OF DELAWARE · PI BAHNSON, BRIAN J · 1994 to 2018
$5.0M
Mechanisms of sex differences in neonatal pulmonary oxygen toxicityR01HL144775 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI LINGAPPAN, KRITHIKA · 2019 to 2023
$2.7M
Pressure in lung development and congenital diaphragmatic herniaR01HL133163 · NHLBI · UNIVERSITY OF DELAWARE · PI GLEGHORN, JASON PAUL · 2017 to 2021
$1.9M
Mechanisms of sex specific differences in neonatal hyperoxic lung injuryK08HL127103 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LINGAPPAN, KRITHIKA · 2015 to 2019
$816k
Zeiss LSM710 Inverted Confocal MicroscopeS10OD016361 · OD · UNIVERSITY OF DELAWARE · PI CAPLAN, JEFFREY L · 2015 to 2015
$444k
Sex as biological variable in Bronchopulmonary Dysplasia: Role of the Notch pathwayR21HD100862 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI LINGAPPAN, KRITHIKA · 2020 to 2021
$441k
Arsenic-mediated fibrosis and developmental dysregulation in the fetal lungR21ES027962 · NIEHS · UNIVERSITY OF DELAWARE · PI GLEGHORN, JASON PAUL · 2018 to 2019
$411k
Sex-specific differences in neonatal hyperoxic lung injury: Role of the NF-kappa B pathwayR03HL141572 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LINGAPPAN, KRITHIKA · 2018 to 2019
$159k
NHLBI NIH HHS K08 HL127103NHLBI NIH HHS R01 HL133163NHLBI NIH HHS R01 HL144775NHLBI NIH HHS R03 HL141572NICHD NIH HHS R21 HD100862NIEHS NIH HHS R21 ES027962NIGMS NIH HHS T32 GM008550NIH HHS S10 OD016361
6 · The paper itself

Abstract

Premature male neonates are at a greater risk of developing bronchopulmonary dysplasia (BPD). The reasons underlying sexually dimorphic outcomes in premature neonates are not known. The role of miRNAs in mediating sex biases in BPD is understudied. Analysis of the pulmonary transcriptome revealed that a large percentage of angiogenesis-related differentially expressed genes are miR-30a targets. We tested the hypothesis that there is differential expression of miR-30a in vivo and in vitro in neonatal human pulmonary microvascular endothelial cells (HPMECs) upon exposure to hyperoxia. Neonatal male and female mice (C57BL/6) were exposed to hyperoxia [95% fraction of inspired oxygen (Fi

Indexed as

Gene Expression RegulationSex CharacteristicsAnimalsAnimals, NewbornBronchopulmonary DysplasiaEndothelial CellsFemaleHyperoxiaLung InjuryMaleMiceMicroRNAsMicroRNAsMIRN30a microRNA, mouseangiogenesisBPDDll4hyperoxiamiR-30asex

Identifiers

PMID30382766
PMCPMC6383497
OpenAlexW2899189869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.