ArticleJournal of the American Geriatrics Society2019
Protein Intake and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study.
Article in Journal of the American Geriatrics Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Low protein intake, physical activity, and physical function in European and North American community-dwelling older adults: a pooled analysis of four longitudinal aging cohorts.The American journal of clinical nutrition · 2021Pooled it
- Prevalence of protein intake below recommended in community-dwelling older adults: a meta-analysis across cohorts from the PROMISS consortium.Journal of cachexia, sarcopenia and muscle · 2020Pooled it
- The cost effectiveness of personalized dietary advice to increase protein intake in older adults with lower habitual protein intake: a randomized controlled trial.European journal of nutrition · 2022Trial
- Protein intake and transitions between frailty states in middle-aged and older adults: a multi-state transition model in the UK Biobank.BMC medicine · 2025Article
- Animal-derived foods, physical activities, and mild cognitive impairment among Chinese older adults: findings from CLHLS (2008-2018).BMC public health · 2025Article
- Diet in Knee Osteoarthritis-Myths and Facts.Nutrients · 2025Review
- Effect of individually tailored nutritional counseling on frailty status in older adults with protein-energy malnutrition or risk of it: an intervention study among home care clients.European journal of clinical nutrition · 2025Article
- Perspectives on Diet and Exercise Interaction for Healthy Aging: Opportunities to Reduce Malnutrition Risk and Optimize Fitness.Nutrients · 2025Review
- BMI Mediates the Association between Macronutrient Subtypes and Phenotypic Age Acceleration.Nutrients · 2024Article
- Relationship between dietary macronutrients intake and biological aging: a cross-sectional analysis of NHANES data.European journal of nutrition · 2024Article
- Observational
- Prevalence and correlates of malnutrition risk among Chinese centenarians and oldest-old adults.iScience · 2023Article
- Validation of the German version of the Protein Screener 55.European journal of clinical nutrition · 2023Article
- Animal foods and mobility limitations in community-dwelling young-old adults: longitudinal analysis of the EpiDoC cohort.BMC geriatrics · 2022Article
- Relationship between Dietary Macronutrients Intake and the ATHLOS Healthy Ageing Scale: Results from the Polish Arm of the HAPIEE Study.Nutrients · 2022Article
- A review of recent evidence of dietary protein intake and health.Nutrition research and practice · 2022Review
- Article
- Protein intake pattern over the day and its association with low total protein intake in Dutch community-dwelling older adults.Public health nutrition · 2021Article
- Associations of poor oral health with frailty and physical functioning in the oldest old: results from two studies in England and Japan.BMC geriatrics · 2021Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo determine whether protein intake is associated with better disability trajectories in the oldest adults (≥85) and whether muscle mass and muscle strength would partially mediate this.
designProspective cohort study.
settingNewcastle-upon-Tyne and North Tyneside, United Kingdom.
participantsCommunity-dwelling older adults aged 85 at baseline (N=722).
methodsProtein intake was estimated using two 24-hour multiple-pass recalls at baseline. Disability was measured as difficulty performing 17 activities of daily living at baseline and 18, 36, and 60 months. Trajectories were derived using mortality-adjusted group-based trajectory modelling. The effect of protein intake (g/kg of adjusted body weight (aBW)/d) on disability trajectories was examined using multinomial logistic regression.
resultsParticipants had 4 distinct disability trajectories (between the ages of 85 and 90: constant very low (AT1), mild (AT2), moderate (AT3), and severe (AT4). Each unit increase in protein (g) per kg of aBW/d was associated with greater odds of AT1 (odds ratio (OR=7.97, 95% confidence interval (CI)=1.96-32.43, p = .004) and AT2 (OR=3.28, 95% CI=1.09-9.87, p = .03) than of AT4 over 5 years in models adjusted for selected covariates. Participants with protein intake of 1.0 g/kg aBW/d or more were more likely to belong to AT1 (OR=3.65, 95% CI=1.59-8.38, p = .009) and AT2 (OR=2.12, 95% CI=1.16-3.90, p = .01) than to AT4.
conclusionHigher protein intake, especially 1.0 g/kg aBW/d or more, was associated with better disability trajectories in the oldest adults. These findings will inform new dietary strategies to support active, healthy ageing. J Am Geriatr Soc 67:50-56, 2019.
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