Evidence map›Paper›PMID 30382587›Full record

ArticleThe Journal of physiology2019

Protein kinase Cδ constrains the S-pathway to phrenic motor facilitation elicited by spinal 5-HT

Raphael R Perim, Daryl P Fields, Gordon S Mitchell

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  4. Phrenic long-term facilitation following acute intermittent hypercapnic-hypoxia in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2025
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  18. Baseline Arterial COFrontiers in physiology · 2021
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Raphael R PerimCenter for Respiratory Research and Rehabilitation, Department of Physical Therapy and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Daryl P FieldsCenter for Respiratory Research and Rehabilitation, Department of Physical Therapy and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Gordon S MitchellCenter for Respiratory Research and Rehabilitation, Department of Physical Therapy and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-8489-1861
University of Florida · US

Funding

Respiratory plasticity and spinal cord InjuryR37HL069064 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 2002 to 2011
$4.2M
Respiratory Plasticity and Spinal Cord InjuryR01HL069064 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL069064NHLBI NIH HHS R37 HL069064
6 · The paper itself

Abstract

key pointsConcurrent 5-HT ABSTRACT: Intermittent spinal serotonin receptor activation elicits long-lasting phrenic motor facilitation (pMF), a form of respiratory motor plasticity. When activated alone, spinal Gq protein-coupled serotonin 2A receptors (5-HT

Indexed as

AmphetaminesAnimalsCyclic AMP-Dependent Protein KinasesHypoxiaMalePhrenic NerveProtein Kinase C-deltaPyrazolesRats, Sprague-DawleyReceptor, Serotonin, 5-HT2AReceptors, SerotoninSerotonin Receptor AgonistsSpinal CordTetrahydronaphthalenes4-iodo-2,5-dimethoxyphenylisopropylamineAmphetaminesAS 19 compoundCyclic AMP-Dependent Protein KinasesPrkcd protein, ratProtein Kinase C-deltaPyrazolesReceptor, Serotonin, 5-HT2AReceptors, Serotoninserotonin 7 receptorSerotonin Receptor AgonistsTetrahydronaphthalenescross-talk inhibitionphrenic motor facilitationrespiratory motor plasticity

Identifiers

PMID30382587
PMCPMC6332784
OpenAlexW2904151552

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.