Evidence map›Paper›PMID 30382563›Full record

ArticleVirus genes2019

Molecular characterization of hepatitis B virus in blood donors in Botswana.

Wonderful T Choga, Motswedi Anderson, Edward Zumbika, Sikhulile Moyo, Tshepiso Mbangiwa, Bonolo B Phinius, Pinkie Melamu, Mukendi K Kayembe, Ishmael Kasvosve, Theresa K Sebunya and 4 more

Open access · greenAbstract read
In one paragraph

Article in Virus genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Wonderful T ChogaResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Motswedi AndersonResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Edward ZumbikaDepartment of Applied Biology and Biochemistry, National University of Science and Technology, Bulawayo, Zimbabwe.
Sikhulile MoyoResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.ORCID http://orcid.org/0000-0003-3821-4592
Tshepiso MbangiwaResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Bonolo B PhiniusResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Pinkie MelamuResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Mukendi K KayembeNational Health Laboratory (NHL), Ministry of Health and Wellness, Gaborone, Botswana.
Ishmael KasvosveDepartment of Medical Laboratory Sciences, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana.
Theresa K SebunyaDepartment of Biological Sciences, University of Botswana, Gaborone, Botswana.
Jason T BlackardUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.
Max EssexResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Rosemary M MusondaResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Simani GaseitsiweResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana. sgaseitsiwe@bhp.org.bw.
Harvard University · USUniversity of Botswana · BWBotswana Harvard AIDS Institute Partnership · BWNational University of Science and Technology · ZWMinistry of Health · BWUniversity of Cincinnati Medical Center · US

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI LEE ARMISTEAD DENSON · 2007 to 2026
$24.4M
Training in HIV Genomics, Treatment, and Cure Research in BotswanaD43TW009610 · FIC · THE BOTSWANA HARVARD HEALTH PARTNERSHIP · PI SHAHIN LOCKMAN, Joseph Moeketsi Makhema · 2013 to 2026
$4.4M
FIC NIH HHS D43 TW009610NIDDK NIH HHS P30 DK078392SANTHE DEL-15-006Wellcome TrustWellcome Trust 107752/Z/15/Z
6 · The paper itself

Abstract

Hepatitis B virus (HBV) poses a significant threat to blood transfusion safety in sub-Saharan Africa (SSA) where allogeneic blood donations are screened serologically, and more sensitive nucleic acid tests (NATs) are utilized infrequently. HBV strains circulating among blood donors in Botswana are not yet characterized. We designed a cross-sectional study to determine the HBV sub-genotypes and prevalence of hepatitis B surface antigen (HBsAg) among blood donors between November 2014 and October 2015. A total of 12,575 blood donations were screened for HBsAg and 50 consecutive plasma samples were selected for genotyping from confirmed HBsAg

Indexed as

Blood DonorsAdolescentAdultAgedAmino Acid SequenceBotswanaCross-Sectional StudiesDNA, ViralFemaleGenotypeHepatitis BHepatitis B virusHumansMaleMiddle AgedMutationDNA, ViralBlood donorsBotswanaHBVMutationsSub-genotypes

Identifiers

PMID30382563
PMCPMC6563613
OpenAlexW2899045634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.