Evidence map›Paper›PMID 30382519›Full record

ReviewEnvironmental science and pollution research international2018

Per- and polyfluoroalkyl substances in human breast milk and current analytical methods.

Linda R Macheka-Tendenguwo, Joshua O Olowoyo, Liziwe L Mugivhisa, Ovokeroye A Abafe

Abstract readReview
PubMed Publisher
In one paragraph

Review in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Linda R Macheka-TendenguwoSefako Makgatho Health Sciences University, Pretoria, South Africa. misslindamacheka@gmail.com.ORCID http://orcid.org/0000-0001-9730-6919
Joshua O OlowoyoSefako Makgatho Health Sciences University, Pretoria, South Africa.
Liziwe L MugivhisaSefako Makgatho Health Sciences University, Pretoria, South Africa.
Ovokeroye A AbafeAgricultural Research Council-OVR, Pretoria, South Africa.
Sefako Makgatho Health Sciences University · ZAAgricultural Research Council of South Africa · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFASs) have since become a major health concern as they have been reportedly found in human tissues, blood and breast milk. The main aim of the study was to review the current data on PFASs in human breast milk, including the challenges of analysis as well as the possible modes of transfer from maternal blood. In this paper, previously published data on the concentrations of PFASs in human breast milk from around the world were reviewed and summarised. Eligible studies with reference lists published before 1 June 2017 were included by searching several databases (including Scopus, ScienceOpen and SciFinder). From this search, studies with the number of participants in each study ranging from 2 to 1237 were identified. The review indicated that based on the structural profiles and concentration levels, there was variation in the geographical distribution of these compounds in breast milk. Although there are no recorded investigations on the modes of transfer from maternal blood to breast milk, literature suggests that the PFASs tend to be transferred through binding to various proteins. The review also examined the different sample preparation and analytical methods employed to measure the concentrations of PFASs in human breast milk. This showed that solid phase extraction was the most common extraction method. After extraction, liquid chromatography coupled with tandem mass spectrometry was the most common analysis method. Since several of these methods were initially dedicated to monitoring PFASs in food and water, they demonstrate some limitations with regard to specificity and sensitivity to human fluids. Additionally, there are currently no published records of certified reference materials and/or proficiency scheme devoted to standardising PFAS concentrations in breast milk.

Indexed as

Breast FeedingChromatography, GasChromatography, LiquidEnvironmental PollutantsFemaleFluorocarbonsHumansMilk, HumanSolid Phase ExtractionSpecimen HandlingTandem Mass SpectrometryEnvironmental PollutantsFluorocarbonsBiomonitoringHuman breast milkPerfluoroalkyl substancesPerfluorooctane sulphonatePerfluorooctanoic acid

Identifiers

PMID30382519
OpenAlexW2899224497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.