ArticleAnnals of intensive care2018
Pleural effusion during weaning from mechanical ventilation: a prospective observational multicenter study.
Article in Annals of intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Drainage of Pleural Effusion in the Intensive Care Unit (DOPE-ICU) Feasibility Trial-Protocol and Statistical Analysis Plan.Acta anaesthesiologica Scandinavica · 2026Article
- Effects of Thoracentesis in Patients Under Invasive Mechanical Ventilation: A Retrospective Analysis of Clinical and Paraclinical Parameters.Journal of clinical medicine · 2026Article
- Weaning failure from mechanical ventilation: a scoping review of the utility of ultrasonography in the weaning process.British journal of anaesthesia · 2025Article
- Role of interventional pulmonology in intensive care units: A scoping review.World journal of critical care medicine · 2025Review
- Predicting Successful Weaning through Sonographic Measurement of the Rapid Shallow Breathing Index.Journal of clinical medicine · 2024Article
- Pleural effusion in critically ill patients and intensive care setting.World journal of clinical cases · 2023Review
- Can Lung Ultrasound Be the Ideal Monitoring Tool to Predict the Clinical Outcome of Mechanically Ventilated COVID-19 Patients? An Observational Study.Healthcare (Basel, Switzerland) · 2022Article
- Risk Factors for Mortality Among Mechanically Ventilated Patients Requiring Pleural Drainage.International journal of general medicine · 2022Article
- Ultrasound-Guided Pleural Effusion Drainage: Effect on Oxygenation, Respiratory Mechanics, and Liberation from Mechanical Ventilation in Surgical Intensive Care Unit Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Small Drainage Volumes of Pleural Effusions Are Associated with Complications in Critically Ill Patients: A Retrospective Analysis.Journal of clinical medicine · 2021Article
- Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus.Critical care (London, England) · 2020Review
- Feasibility and efficacy of lung ultrasound to investigate pulmonary complications in patients who developed postoperative Hypoxaemia-a prospective study.BMC anesthesiology · 2020Article
- Real-time ultrasound-guided thoracentesis in the intensive care unit: prevalence of mechanical complications.The ultrasound journal · 2020Article
- Thoracic ultrasonography: a narrative review.Intensive care medicine · 2019Review
- Lung ultrasound estimation of pleural effusion fluid and the importance of patient position.Annals of intensive care · 2018Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPleural effusion is common during invasive mechanical ventilation, but its role during weaning is unclear. We aimed at assessing the prevalence and risk factors for pleural effusion at initiation of weaning. We also assessed its impact on weaning outcomes and its evolution in patients with difficult weaning.
methodsWe performed a prospective multicenter study in five intensive care units in France. Two hundred and forty-nine patients were explored using ultrasonography. Presence of moderate-to-large pleural effusion (defined as a maximal interpleural distance ≥ 15 mm) was assessed at weaning start and during difficult weaning.
resultsSeventy-three (29%) patients failed weaning, including 46 (18%) who failed the first spontaneous breathing trial (SBT) and 39 (16%) who failed extubation. Moderate-to-large pleural effusion was detected in 81 (33%) patients at weaning start. Moderate-to-large pleural effusion was associated with more failures of the first SBT [27 (33%) vs. 19 (11%), p < 0.001], more weaning failures [37 (47%) vs. 36 (22%), p < 0.001], less ventilator-free days at day 28 [21 (5-24) vs. 23 (16-26), p = 0.01], and a higher mortality at day 28 [14 (17%) vs. 14 (8%), p = 0.04]. The association of pleural effusion with weaning failure persisted in multivariable analysis and sensitivity analyses. Short-term (48 h) fluid balance change was not associated with the evolution of interpleural distance in patients with difficult weaning.
conclusionsIn this multicenter observational study, pleural effusion was frequent during the weaning process and was associated with worse weaning outcomes.
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