Evidence map›Paper›PMID 30382469›Full record

ArticleJournal of assisted reproduction and genetics2019

Altered expression of the kisspeptin/KISS1R and neurokinin B/NK3R systems in mural granulosa and cumulus cells of patients with polycystic ovarian syndrome.

Victor Blasco, Francisco M Pinto, Ainhoa Fernández-Atucha, Nicolás Prados, Manuel Tena-Sempere, Manuel Fernández-Sánchez, Luz Candenas

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. New Insights in Bovine Follicular Cysts.Reproduction in domestic animals = Zuchthygiene · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Neuroendocrine Determinants of Polycystic Ovary Syndrome.International journal of environmental research and public health · 2022
    Review
  10. Targeting Elevated GnRH Pulsatility to Treat Polycystic Ovary Syndrome.The Journal of clinical endocrinology and metabolism · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Victor BlascoInstituto de Investigaciones Químicas, CSIC, Avenida Americo Vespucio 49, 41092, Seville, Spain.
Francisco M PintoInstituto de Investigaciones Químicas, CSIC, Avenida Americo Vespucio 49, 41092, Seville, Spain.
Ainhoa Fernández-AtuchaDepartamento de Fisiología, Universidad del País Vasco, Leioa, Bizkaia, Spain.
Nicolás PradosIVI-RMA Global, Seville, Spain.
Manuel Tena-SempereDepartamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Córdoba, Spain.
Manuel Fernández-SánchezIVI-RMA Global, Seville, Spain.
Luz CandenasInstituto de Investigaciones Químicas, CSIC, Avenida Americo Vespucio 49, 41092, Seville, Spain. luzcandenas@iiq.csic.es.ORCID http://orcid.org/0000-0001-7886-1095
IVI Sevilla Clinic · ESInstituto de Investigaciones Químicas · ESInstituto de Salud Carlos III · ESUniversity of the Basque Country · ES

Funding

Ministerio de Economía y Competitividad, Spain RTC-2014-1431-1
6 · The paper itself

Abstract

purposeThe neurokinin B (NKB)/NK

methodsA cross-sectional study was performed in 46 healthy women and 43 PCOS women undergoing controlled ovarian stimulation. MGCs and CCs were collected from pre-ovulatory follicles after transvaginal ultrasound-guided oocyte retrieval and the expression of the genes encoding NKB (TAC3), NK3R (TACR3), KISS1, and its receptor (KISS1R) was analyzed using real-time quantitative RT-PCR.

resultsTAC3, TACR3, and KISS1 mRNA levels were decreased in MGCs and CCs of PCOS women. TAC3 positively correlated with KISS1 in MGCs of healthy women and TACR3 was positively associated with KISS1R in CCs from healthy women. These associations were not observed in PCOS women.

conclusionThe NKB/NK3R and KISS1/KISS1R systems are dysregulated in MGCs and CCs of PCOS women. The lower expression of these systems in GCs could contribute to the abnormal follicle development and defective ovulation that characterize the pathogenesis of PCOS.

Indexed as

AdultCase-Control StudiesCells, CulturedCross-Sectional StudiesCumulus CellsFemaleGene Expression RegulationGranulosa CellsHumansKisspeptinsNeurokinin BPolycystic Ovary SyndromeReceptors, Kisspeptin-1Receptors, Neurokinin-3Young AdultKISS1 protein, humanKISS1R protein, humanKisspeptinsNeurokinin BReceptors, Kisspeptin-1Receptors, Neurokinin-3TAC3 protein, humanTACR3 protein, humanCumulus cellsGranulosa cellsKisspeptinNeurokinin BPolycystic ovarian syndrome

Identifiers

PMID30382469
PMCPMC6338604
OpenAlexW2899234166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.