ArticleBiogerontology2019
Extensive growth is followed by neurodegenerative pathology in the continuously expanding adult zebrafish retina.
Article in Biogerontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Harnessing PDX and PDX 2.0: the next-generation paradigm for precision oncology and translational breakthroughs.Molecular cancer · 2026Review
- Fish Models of Ageing Retinal Disease.Advances in experimental medicine and biology · 2025Review
- Differential retinal ganglion cell resilience to optic nerve injury across vertebrate species.Frontiers in neuroscience · 2025Article
- Age-related dysregulation of the retinal transcriptome in African turquoise killifish.Aging cell · 2024Article
- C9ORF72 Deficiency Results in Neurodegeneration in the Zebrafish Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Age-related dysregulation of the retinal transcriptome in African turquoise killifish.bioRxiv : the preprint server for biology · 2024Article
- Ultrastructural Characteristics and Synaptic Connectivity of Photoreceptors in the Simplex Retina of Little Skate (eNeuro · 2023Article
- Tissue stretching is a confounding factor for the evaluation of neurodegeneration in the fast-ageing killifish.Biogerontology · 2023Article
- Müller Glia maintain their regenerative potential despite degeneration in the aged zebrafish retina.Aging cell · 2022Article
- The age factor in optic nerve regeneration: Intrinsic and extrinsic barriers hinder successful recovery in the short-living killifish.Aging cell · 2022Article
- Differential Responses of Neural Retina Progenitor Populations to Chronic Hyperglycemia.Cells · 2021Article
- Decline in Constitutive Proliferative Activity in the Zebrafish Retina with Ageing.International journal of molecular sciences · 2021Article
- The killifish visual system as an in vivo model to study brain aging and rejuvenation.NPJ aging and mechanisms of disease · 2021Article
- Visual Function is Gradually Restored During Retina Regeneration in Adult Zebrafish.Frontiers in cell and developmental biology · 2021Article
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Authors and funding
9 authors.
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Abstract
The development of effective treatments for age-related neurodegenerative diseases remains one of the biggest medical challenges today, underscoring the high need for suitable animal model systems to improve our understanding of aging and age-associated neuropathology. Zebrafish have become an indispensable complementary model organism in gerontology research, yet their growth-control properties significantly differ from those in mammals. Here, we took advantage of the clearly defined and highly conserved structure of the fish retina to study the relationship between the processes of growth and aging in the adult zebrafish central nervous system (CNS). Detailed morphological measurements reveal an early phase of extensive retinal growth, where both the addition of new cells and stretching of existent tissue drive the increase in retinal surface. Thereafter, and coinciding with a significant decline in retinal growth rate, a neurodegenerative phenotype becomes apparent,-characterized by a loss of synaptic integrity, an age-related decrease in cell density and the onset of cellular senescence. Altogether, these findings support the adult zebrafish retina as a valuable model for gerontology research and CNS disease modeling and will hopefully stimulate further research into the mechanisms of aging and age-related pathology.
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