ReviewArchives of osteoporosis2018
A brief history of FRAX.
Review in Archives of osteoporosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Ukrainian guideline for the prevention and treatment of glucocorticoid-induced osteoporosis.Archives of osteoporosis · 2025Guideline
- Diagnosis and management of osteoporosis in Saudi Arabia: 2023 key updates from the Saudi Osteoporosis Society.Archives of osteoporosis · 2023Pooled it
- Systematic review of major osteoporotic fracture to hip fracture incidence rate ratios worldwide: implications for Fracture Risk Assessment Tool (FRAX)-derived estimates.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Pooled it
- Objective Physical Performance Predicts 10-Year Fracture Risk Without Densitometry in Older Men and Women: Development and Head-to-Head Comparison with FRAX in MrOS and SOF.Calcified tissue international · 2026Article
- Osteoporosis and adult spinal deformity-a review for spinal surgeons by the SRS adult spinal deformity task force on senescence.Spine deformity · 2026Review
- Clinical and Laboratory Predictors of Bone Mineral Density Trajectories and Osteoporosis Progression: A Retrospective Longitudinal Cohort Study.Journal of clinical medicine · 2026Article
- Parity, age at first birth, breastfeeding, and risk of major osteoporotic fractures in middle-aged women. The HUNT study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Community-based osteoporosis prescreening using FRAX and portable pulse-echo ultrasound: a pilot study from Western Austria.Archives of osteoporosis · 2026Article
- Ten-year re-validation of the fracture risk assessment tool (FRAX®) in Taiwan.Archives of osteoporosis · 2026Article
- Early Identification of Low Bone Density Risk Using a Radiofrequency Echographic Multi Spectrometry-Based Prediction Model.Life (Basel, Switzerland) · 2026Article
- Computed Tomography Attenuation of Bone Predicts Incident Fracture in Patients With Anorectal Cancer Treated With Radiation.Advances in radiation oncology · 2026Article
- The emerging role of ¹⁸F-NaF PET/CT in osteoporosis: an emphasis on its application for the evaluation and management of lumbar spine osteoporosis.EJNMMI research · 2026Review
- Impact of osteoporosis pharmacotherapy and vitamin d supplementation on fracture morphology and treatment of pelvic fragility fractures: a retrospective cohort study of 1493 patients from the German Pelvic Trauma Registry.Archives of osteoporosis · 2026Article
- Epidemiology of hip fractures in Costa Rica and development of country- specific thresholds to estimate fracture risk.Archives of osteoporosis · 2026Article
- Personalized intensification of treatment for hormone-sensitive prostate cancer.Nature reviews. Clinical oncology · 2026Review
- The interrelationship between prostate cancer and osteoporosis: new perspectives on shared molecular pathways and treatment strategies.International journal of surgery (London, England) · 2026Article
- Article
- Osteoporosis Knowledge of Older Women with Fragility Fractures: A Cross-Sectional Study Based on Latent Profile Analysis.Clinical interventions in aging · 2026Article
- Advancing fracture risk prediction: established assessment tools and emerging HR-pQCT-based approaches.Frontiers in endocrinology · 2026Review
- Traditional clinical risk factors outperform disease activity and hematologic indices for FRAX hip fracture risk in rheumatoid arthritis.Frontiers in immunology · 2026Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This paper reviews the research programme that went into the development of FRAX® and its impact in the 10 years since its release in 2008.
introductionOsteoporosis is defined on the measurement of bone mineral density though the clinical consequence is fracture. The sensitivity of bone mineral density measurements for fracture prediction is low, leading to the development of FRAX to better calculate the likelihood of fracture and target anti-osteoporosis treatments.
methodsThe method used in this paper is literature review.
resultsFRAX, developed over an 8-year period, was launched in 2008. Since the launch of FRAX, models have been made available for 64 countries and in 31 languages covering more than 80% of the world population.
conclusionFRAX provides an advance in fracture risk assessment and a reference technology platform for future improvements in performance characteristics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.