ReviewCurrent rheumatology reports2018
Clinical Perspective on Pain and Pain Phenotypes in Osteoarthritis.
Review in Current rheumatology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Osteoarthritis: molecular pathogenesis and potential therapeutic options.Signal transduction and targeted therapy · 2026Review
- Neuropeptide Y signaling in osteoarthritis pain: neuroimmune mechanisms, joint remodeling, and translational opportunities.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Latent class analysis identifies distinct pain phenotypes in newly diagnosed systemic juvenile idiopathic arthritis.Arthritis research & therapy · 2025Article
- Beyond the Hip: Clinical Phenotypes of Hip Osteoarthritis Across the Biopsychosocial Spectrum.Journal of clinical medicine · 2024Article
- Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives.Pain and therapy · 2024Review
- Nociceptor spontaneous activity is responsible for fragmenting non-rapid eye movement sleep in mouse models of neuropathic pain.Science translational medicine · 2024Article
- Phenotypes of osteoarthritis-related knee pain and their transition over time: data from the osteoarthritis initiative.BMC musculoskeletal disorders · 2024Article
- Personal factors and baseline function in patients undergoing non-operative management for chronic hip-related groin pain: a cross-sectional study.BMJ open sport & exercise medicine · 2023Article
- Intra-articular MMP-1 in the spinal facet joint induces sustained pain and neuronal dysregulation in the DRG and spinal cord, and alters ligament kinematics under tensile loading.Frontiers in bioengineering and biotechnology · 2022Article
- Pain descriptors and determinants of pain sensitivity in knee osteoarthritis: a community-based cross-sectional study.Rheumatology advances in practice · 2022Article
- Osteoarthritis Research Society International (OARSI): Past, present and future.Osteoarthritis and cartilage open · 2021Review
- Involvement of Macrophages and Spinal Microglia in Osteoarthritis Pain.Current rheumatology reports · 2021Review
- Intra-articular targeting of nanomaterials for the treatment of osteoarthritis.Acta biomaterialia · 2019Review
- Ligustilide attenuates nitric oxide-induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways.Journal of cellular and molecular medicine · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewPain is the most prominent symptom in osteoarthritis. Pain experience is a complex and multifactorial phenomenon. This review, therefore, offers a brief overview of the literature on factors from main pain dimensions and summarizes current evidence for identifying pain phenotypes in knee osteoarthritis. RECENT
findingsPeripheral structural damage has been traditionally considered a source of pain and this has strengthened with MRI studies; however, a discordance between structural damage and pain severity suggests individual variations in pain presentation which may be determined by genetic, environmental (obesity), psychological, and neurological factors. Each of the factors may play its role or intact with other factors to contribute to the variation which can partly explain the overall lack of treatment efficacy with the current "one-size-fits-all" treatment approach. Identifying pain phenotypes in knee osteoarthritis is promising to develop individualized treatments; however, the validity and reliability of osteoarthritis pain phenotypes have not been tested in clinical practice. Given the heterogeneity of osteoarthritis pain, peripheral, psychological, and neurological factors are considered key phenotypic dimensions in the identification of pain phenotypes. This new concept allows for patients' stratification for clinical trials, thus providing the potential for individualized interventions in patients with osteoarthritis pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.