ArticleJournal of neural transmission (Vienna, Austria : 1996)2019
Cerebral perfusion abnormalities in patients with persistent postural-perceptual dizziness (PPPD): a SPECT study.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Neuroimaging studies in persistent postural-perceptual dizziness and related disease: a systematic review.Journal of neurology · 2022Pooled it
- Persistent postural-perceptual dizziness (PPPD): the most common cause of chronic dizziness.Japanese journal of radiology · 2026Review
- Persistent postural-perceptual dizziness versus vestibular migraine: A narrative review.Headache · 2026Review
- Spatial Orientation Impairment in Patients With Bilateral Vestibulopathy and Persistent Postural-Perceptual Dizziness.Brain and behavior · 2025Article
- Abnormal neural circuits and altered brain network topological properties in patients with persistent postural-perceptual dizziness.Communications biology · 2025Article
- Research Progress on the Potential Pathogenesis of Persistent Postural-Perceptual Dizziness.Brain and behavior · 2025Review
- Repetitive transcranial magnetic stimulation as add-on the rapyin persistent postural-perceptual dizziness.IBRO neuroscience reports · 2024Article
- Graviception Uncertainty, Spatial Anxiety, and Derealization in Patients with Persistent Postural-Perceptual Dizziness.Journal of clinical medicine · 2024Article
- Persistent Postural-Perceptual Dizziness (PPPD) from Brain Imaging to Behaviour and Perception.Brain sciences · 2022Article
- Altered Neuromagnetic Activity in Persistent Postural-Perceptual Dizziness: A Multifrequency Magnetoencephalography Study.Frontiers in human neuroscience · 2022Article
- Cerebral perfusion changes in chronic dizziness: A single-photon emission computed tomography study.eNeurologicalSci · 2021Article
- Visual snow syndrome, the spectrum of perceptual disorders, and migraine as a common risk factor: A narrative review.Headache · 2021Review
- Brain Correlates of Persistent Postural-Perceptual Dizziness: A Review of Neuroimaging Studies.Journal of clinical medicine · 2021Review
- A Review of Neuroimaging Studies in Persistent Postural-Perceptual Dizziness (PPPD).Nuclear medicine and molecular imaging · 2021Review
- Association of regional cerebral perfusion impairment with gait and balance performance in dizzy patients using brain perfusion SPECT: Voxel-based analysis of a pilot sample.Asia Oceania journal of nuclear medicine & biology · 2021Article
- Altered Regional Cerebral Blood Perfusion in Mild Cognitive Impairment Patients with Dizziness.Diagnostics (Basel, Switzerland) · 2020Article
- Lower Functional Connectivity in Vestibular-Limbic Networks in Individuals With Subclinical Agoraphobia.Frontiers in neurology · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent postural-perceptual dizziness (PPPD) is a recently defined syndrome with chronic dizziness interrupting daily life. Although the high levels of anxiety and functional changes in postural control strategy and multi-sensory information processing and integration may be underlying the pathophysiology, its neural mechanisms are poorly understood. The aim of this study was to examine the regional cerebral blood flow (rCBF) in patients with PPPD using single photon emission computed tomography (SPECT). A total of 25 patients with PPPD and 25 healthy controls participated in the study. All participants underwent brain SPECT and the patients completed the Dizziness Handicap Inventory. SPECT images were compared between the groups, and the correlation of rCBF and disease severity/duration was assessed in patients. Compared with controls, PPPD patients showed a significantly decreased rCBF in the insula and frontal lobe, mainly in the left posterior insula, bilateral superior frontal gyrus, right inferior frontal gyrus, right precentral gyrus, and left medial orbital gyrus. Additionally, PPPD patients showed a significant rCBF increase in the bilateral cerebellum compared with controls. The results of our study suggest that the altered rCBF in the insular, frontal, and cerebellar cortices might be reflecting the process of maladaptation and the compensatory responses for the changes in PPPD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.