ArticleJournal of neurology2019
Cardiovascular autonomic neuropathy and falls in Parkinson disease: a prospective cohort study.
Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Prognostic factors for falls in Parkinson's disease: a systematic review.Acta neurologica Belgica · 2024Pooled it
- Prevalence of freezing of gait in Parkinson's disease: a systematic review and meta-analysis.Journal of neurology · 2021Pooled it
- Management of Hypertension and Blood Pressure Dysregulation in Patients with Parkinson's Disease-a Systematic Review.Current hypertension reports · 2021Pooled it
- Prevalence of postural hypotension in primary, community and institutional care: a systematic review and meta-analysis.BMC family practice · 2021Pooled it
- Prevalence and incidence of orthostatic hypotension in patients with Parkinson's disease: an updated systematic review and meta-analysis.Frontiers in neurologyPooled it
- Effects of Blood Flow Restriction Resistance Training on Autonomic and Endothelial Function in Persons with Parkinson's Disease.Journal of Parkinson's disease · 2024Trial
- Article
- Orthostatic hypotension in Parkinson disease.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Searching for a needle in a haystack-ambulatory research in Parkinson's disease in Germany.Frontiers in aging neuroscience · 2026Article
- Exploring the relationship between orthostatic hypotension and gait in people with Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Delayed orthostatic hypotension in Parkinson's disease and in the general ageing population.Age and ageing · 2025Article
- Advances in autonomic dysfunction research in Parkinson's disease.Frontiers in aging neuroscience · 2025Review
- Unraveling the stride: exploring the influence of neurogenic orthostatic hypotension on gait and balance in Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- TMS of the left primary motor cortex improves tremor intensity and postural control in primary orthostatic tremor.Journal of neurology · 2024Article
- Hypotensive episodes at 24-h ambulatory blood pressure monitoring predict adverse outcomes in Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- The impact of cardiovascular diagnostics and treatments on fall risk in older adults: a scoping review and evidence map.GeroScience · 2024Article
- Burden of caregiving for cardiovascular dysautonomia in Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Freezing of Gait in Multiple System Atrophy.Frontiers in aging neuroscience · 2022Article
- The influence of probable rapid eye movement sleep behavior disorder and sleep insufficiency on fall risk in a community-dwelling elderly population.BMC geriatrics · 2021Article
- Association of Orthostatic Hypotension With Cerebral Atrophy in Patients With Lewy Body Disorders.Neurology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFalls represent one of the main complications of Parkinson's disease (PD), significantly lowering quality of life. Cardiovascular autonomic neuropathy (cAN) is one of the key contributing factors to PD-associated falls. However, a direct quantification of its impact on the risk of falling in PD is still lacking. In this 12-month prospective study, we sought to evaluate the association between cAN and falls.
methodsFifty consecutive patients were evaluated with a standardized battery of autonomic testing, Unified Parkinson's Disease Rating Scale, push and release (P&R) test, timed up and go test, freezing of gait (FOG) questionnaire, Montreal cognitive assessment (MoCA). Dyskinesia severity and presence of REM sleep behavioral disorder (RBD) were additionally considered. Patients were followed-up for 12 months.
resultsWe observed a 38% prevalence of cAN. At baseline, 36% of patients reported at least one fall in the previous 6 months. This figure increased to 56% over the follow-up. After adjusting for age, disease duration, axial symptoms, MoCA and dopaminergic treatment, cAN was significantly associated with a 15-fold (OR 15.194) higher probability of falls; orthostatic hypotension (OH), the most common expression of cAN, with a 10-fold probability (OR 10.702). In addition P&R test (OR 14.021), RBD (OR 5.470) and FOG (OR 1.450) were independently associated with greater probability of falls.
conclusionscAN, including but not limited to OH, is a strong independent predictor of falls in PD. Future research endeavors clarifying to what extent pharmacological and non-pharmacological treatments targeting autonomic dysfunctions might reduce the risk of falls are warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.