Evidence map›Paper›PMID 30382373›Full record

ReviewHistochemistry and cell biology2018

The role of autophagy in morphogenesis and stem cell maintenance.

Eric Bekoe Offei, Xuesong Yang, Beate Brand-Saberi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Histochemistry and cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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  7. Review
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  9. Review
  10. In focus in HCB.Histochemistry and cell biology · 2020
    Article
  11. In focus in HCB.Histochemistry and cell biology · 2020
    Article
  12. Article
  13. In focus in HCB.Histochemistry and cell biology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Eric Bekoe OffeiDepartment of Anatomy and Molecular Embryology, Institute of Anatomy, Ruhr University Bochum, Universitätsstrasse 150, 44801, Bochum, Germany.
Xuesong YangDivision of Histology and Embryology, Medical College, Jinan University, No 601 Huangpu Road West, Guangzhou, 510632, People's Republic of China.
Beate Brand-SaberiDepartment of Anatomy and Molecular Embryology, Institute of Anatomy, Ruhr University Bochum, Universitätsstrasse 150, 44801, Bochum, Germany. Beate.Brand-Saberi@rub.de.
Ruhr University Bochum · DEJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During embryonic development, cells need to undergo a number of morphological changes that are decisive for the shaping of the embryo's body, initiating organogenesis and differentiation into functional tissues. These remodeling processes are accompanied by profound changes in the cell membrane, the cytoskeleton, organelles, and extracellular matrix composition. While considerably detailed insight into the role of autophagy in stem cells biology has been gained in the recent years, information regarding the participation of autophagy in morphogenetic processes is only sparse. This review, therefore, focuses on the role of autophagy in cell morphogenesis through its regulatory activity in TGFβ signaling, expression of adhesion molecules and cell cycle modification. It also discusses the role of autophagy in stem cell maintenance which is very fundamental for cell renewal and replacement during development, pathogenesis of certain diseases and development of therapies. We are thus addressing here perspectives for further potentially rewarding research topics.

Indexed as

AutophagyMorphogenesisAnimalsHumansStem CellsAtg genesAutophagyCancerEMTMorphogenesisPluripotent stem cells

Identifiers

PMID30382373
OpenAlexW2899281695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.