ArticleAnalytical and bioanalytical chemistry2019
3D printed microfluidic devices with immunoaffinity monoliths for extraction of preterm birth biomarkers.
Article in Analytical and bioanalytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 63 citations in OpenAlex.
- High-resolution 3D-printed insulator-based dielectrophoresis devices for biomolecular manipulation.Analytical and bioanalytical chemistry · 2026Article
- Advancing the Applications of 3D Printed Microfluidics: Utilizing Quantum Dots to Measure Internal Temperature.International journal of heat and mass transfer · 2025Article
- Revolutionizing healthcare with nanosensor technology.RSC advances · 2025Review
- 3D Printed Microfluidic Devices for Integrated Immunoaffinity Extraction, Solid-Phase Extraction, and Fluorescent Labeling of Preterm Birth Biomarkers.Precision chemistry · 2025Article
- Digital light processing 3D printing of microfluidic devices targeting high-pressure liquid-phase separations.Mikrochimica acta · 2024Article
- Monolithic affinity columns in 3D printed microfluidics for chikungunya RNA detection.Analytical and bioanalytical chemistry · 2023Article
- Review
- Past, current, and future roles of 3D printing in the development of capillary electrophoresis systems.Trends in analytical chemistry : TRAC · 2023Article
- 3D printed spinning cup-shaped device for immunoaffinity solid-phase extraction of diclofenac in wastewaters.Mikrochimica acta · 2022Article
- Immunoaffinity monoliths for multiplexed extraction of preterm birth biomarkers from human blood serum in 3D printed microfluidic devices.The Analyst · 2022Article
- Affinity monolith chromatography: A review of general principles and recent developments.Electrophoresis · 2021Review
- Multilabel hybridization probes for sequence-specific detection of sepsis-related drug resistance genes in plasmids.Talanta open · 2021Article
- Can 3D Printing Bring Droplet Microfluidics to Every Lab?-A Systematic Review.Micromachines · 2021Review
- Low-cost and open-source strategies for chemical separations.Journal of chromatography. A · 2021Review
- 3D-Printed Microfluidic Droplet Generator with Hydrophilic and Hydrophobic Polymers.Micromachines · 2021Article
- 3D Printed Microfluidic Devices for Solid-Phase Extraction and On-Chip Fluorescent Labeling of Preterm Birth Risk Biomarkers.Analytical chemistry · 2020Article
- A 3D Printed Jet Mixer for Centrifugal Microfluidic Platforms.Micromachines · 2020Article
- 3D Printed Microfluidics.Annual review of analytical chemistry (Palo Alto, Calif.) · 2020Review
- Biocompatible PEGDA Resin for 3D Printing.ACS applied bio materials · 2020Article
- Confinement of Monolithic Stationary Phases in Targeted Regions of 3D-Printed Titanium Devices Using Thermal Polymerization.Analytical chemistry · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Preterm birth (PTB) is defined as birth before the 37th week of pregnancy and results in 15 million early deliveries worldwide every year. Presently, there is no clinical test to determine PTB risk; however, a panel of nine biomarkers found in maternal blood serum has predictive power for a subsequent PTB. A significant step in creating a clinical diagnostic for PTB is designing an automated method to extract and purify these biomarkers from blood serum. Here, microfluidic devices with 45 μm × 50 μm cross-section channels were 3D printed with a built-in polymerization window to allow a glycidyl methacrylate monolith to be site-specifically polymerized within the channel. This monolith was then used as a solid support to attach antibodies for PTB biomarker extraction. Using these functionalized monoliths, it was possible to selectively extract a PTB biomarker, ferritin, from buffer and a human blood serum matrix. This is the first demonstration of monolith formation in a 3D printed microfluidic device for immunoaffinity extraction. Notably, this work is a crucial first step toward developing a 3D printed microfluidic clinical diagnostic for PTB risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.