Evidence map›Paper›PMID 30382294›Full record

ArticleThe Journal of membrane biology2018

The Natural Compound Cinnamaldehyde is a Novel Activator of Calcium-Activated Chloride Channel.

Yayue Huang, Shuai Guo, Shuxi Ren, Yafei Chen, Yong Zhan, Hailong An

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of membrane biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Toxic medicine used in Traditional Chinese Medicine for cancer treatment: are ion channels involved?Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022
    Article
  2. Article
  3. An outer-pore gate modulates the pharmacology of the TMEM16A channel.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  4. The CaActa pharmaceutica Sinica. B · 2021
    Review
  5. Review
  6. Pharmacological Inhibition and Activation of the CaInternational journal of molecular sciences · 2020
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Yayue HuangKey Laboratory of Molecular Biophysics, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China.ORCID 0000-0001-6364-803X
Shuai GuoState Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, China.ORCID 0000-0002-5342-9666
Shuxi RenKey Laboratory of Molecular Biophysics, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China.ORCID 0000-0001-6388-6441
Yafei ChenKey Laboratory of Molecular Biophysics, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China.ORCID 0000-0001-7792-5317
Yong ZhanState Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, China.ORCID 0000-0002-2679-7703
Hailong AnState Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, China. hailong_an@hebut.edu.cn.ORCID 0000-0001-7947-357X
Hebei University of Technology · CN

Funding

Foundation for the Science and Technology Program of Higher Education Institutions of Hebei Province, China Grant No.Qn2016113the National Natural Science Foundation of China Grant No.11175055the National Natural Science Foundation of China Grant No.11735006the National Natural Science Foundation of China Grant No.11747610the National Natural Science Foundation of China Grant No.31600594the Natural Science Foundation of Hebei Province of China Grant No.C2017202208the Natural Science Foundation of Hebei Province of China Grant No.C2018202302The Youth Talent Support Program of Hebei Province of China Grant No.2013001
6 · The paper itself

Abstract

Calcium-activated chloride channels (CaCCs) play important roles in a multitude of physiological processes, and in many cells types, TMEM16A was identified as the molecular basis of CaCC. Abnormal CaCC function has been implicated in variety of diseases, which reinforces the need for modulators of CaCCs/TMEM16A. However, there are few specific, clinical modulators of CaCCs. Here, we identified a potent novel activator of TMEM16A from a bank of traditional Chinese medicines (TCM) and explored its mechanism of activation by laser confocal scanning microscopy and patch clamping. Fluorescence data demonstrated that among the 36 tested TCM medicines, one compound, cinnamaldehyde (CA), can activate the TMEM16A channel in a dose-dependent manner. To determine the mechanism by which CA activates the TMEM16A channel, we performed an excised patch clamp experiment and measured the intracellular calcium concentration in fluorescence experiments. Our data show that CA activates TMEM16A channels by elevating the intracellular concentrations of calcium ions. The results of the whole-cell patch clamping showed that CA dose-dependently activates these channels, with an EC

Indexed as

AcroleinAnimalsAnoctamin-1CalciumChloride Channel AgonistsChloride ChannelsDrug DiscoveryElectrophysiologyHumansAcroleinAnoctamin-1CalciumChloride Channel AgonistsChloride ChannelscinnamaldehydeCLCA1 protein, humanActivator of CaCC/TMEM16ACinnamaldehydeDrug discoveryElectrophysiologyFluorescent imaging

Identifiers

PMID30382294
OpenAlexW2899227675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.