Observational studyEye (London, England)2019
Ability of swept source OCT to detect retinal changes in patients with bipolar disorder.
Observational study in Eye (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Neuroretinal Alterations in Schizophrenia and Bipolar Disorder: An Updated Meta-analysis.Schizophrenia bulletin · 2024Pooled it
- A Meta-analysis of Retinal Cytoarchitectural Abnormalities in Schizophrenia and Bipolar Disorder.Schizophrenia bulletin · 2020Pooled it
- Retinal Optical Coherence Tomography in Bipolar Disorder: A Scoping Review.Neuropsychobiology · 2025Article
- Optic nerve head neurovascular assessments in patients with schizophrenia: A cross-sectional study.Health science reports · 2024Article
- Optical Coherence Tomography Findings in Bipolar Disorder Patients and the Related Factors.Psychiatry and clinical psychopharmacology · 2023Article
- Sex-Specific Changes in Choroid Vasculature Among Patients with Schizophrenia and Bipolar Disorder.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Bipolar disorders and retinal electrophysiological markers (BiMAR): Study protocol for a comparison of electroretinogram measurements between subjects with bipolar disorder and a healthy control group.Frontiers in psychiatry · 2022Article
- Assessment of Optical Coherence Tomography Findings in Adults with Attention Deficit Hyperactivity Disorder: A Case-Control Study.Psychiatry and clinical psychopharmacology · 2021Article
- Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder.Journal of clinical medicine · 2021Article
- Automatic Diagnosis of Bipolar Disorder Using Optical Coherence Tomography Data and Artificial Intelligence.Journal of personalized medicine · 2021Article
- Retinal layer abnormalities and their association with clinical and brain measures in psychotic disorders: A preliminary study.Psychiatry research. Neuroimaging · 2020Article
- Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer.Brain sciences · 2020Article
- Retinal correlates of psychiatric disorders.Therapeutic advances in chronic disease · 2020Review
- Analysis of retinal nerve fiber layer thickness in anisometropic amblyopia via optic coherence tomography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Optical coherence tomography findings in bipolar disorder - A hospital-based case-control study.Industrial psychiatry journalArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the ability of swept source optical coherence tomography (SS-OCT) to detect retinal changes in patients with bipolar disorder (BD).
methodsTwenty-three patients with BD and 23 controls underwent retinal evaluation using SS deep range imaging (DRI) Triton OCT. Full retinal thickness, the ganglion cell layer (GCL), the retinal nerve fiber layer (RNFL), and choroidal thickness were evaluated with automated segmentation software.
resultsPatients with BD were shown to have significant thinning of the macular full retinal thickness in the center (p = 0.049), inner temporal (p = 0.045), inner nasal (p = 0.016), and inner inferior (p = 0.016) of the ETDRS areas. The macular GCL layer was reduced in patients compared with controls (average, p = 0.002; superior, p = 0.009; superonasal, p = 0.009; inferonasal, p = 0.003; and inferior, p = 0.009). Peripapillary reduction of full retinal thickness (average, p < 0.001; superotemporal, p < 0.001; superonasal, p = 0.003; nasal, p = 0.005; and inferotemporal, p = 0.033), GCL (nasal, p = 0.025), and RNFL thickness (average, p = 0.002; superotemporal, p < 0.001; and superonasal, p = 0.045) was observed in patients compared with controls. No significant differences were observed in choroidal thickness measurements.
conclusionsBD patients were shown to have quantifiable thinning of full retinal thickness and the GCL in the macular area, as well as a peripapillary reduction of the RNFL and GCL thickness. The analysis of the retinal sublayers with SS-OCT may be a useful indicator to show degeneration and monitor disease progression in bipolar disorder.
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