ArticleScientific reports2018
Artificially designed hybrids facilitate efficient generation of high-resolution linkage maps.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Genome refinement in Pacific bluefin tuna (Thunnus orientalis): chromosome-level assembly using hybrid linkage data.BMC genomics · 2026Article
- The impact of telomere-to-telomere genome assembly in the plant pan-genomics era.Breeding science · 2025Article
- Construction of a chromosome-level Japanese stickleback species genome using ultra-dense linkage analysis with single-cell sperm sequencing.NAR genomics and bioinformatics · 2022Article
- Technical considerations in Hi-C scaffolding and evaluation of chromosome-scale genome assemblies.Molecular ecology · 2021Article
- Genomic Evidence for Speciation with Gene Flow in Broadcast Spawning Marine Invertebrates.Molecular biology and evolution · 2021Article
- Chromosome-Scale Genome Assembly and Transcriptome Assembly of KawakawaFrontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
When sequencing eukaryotic genomes, linkage maps are indispensable for building scaffolds to assemble and/or to validate chromosomes. However, current approaches to constructing linkage maps are limited by marker density and cost-effectiveness, especially for wild organisms. We have now devised a new strategy based on artificially generated hybrid organisms to acquire ultrahigh-density genomic markers at reduced cost and build highly accurate linkage maps. We have also developed the novel analysis pipeline Scaffold Extender with Low Depth Linkage Analysis (SELDLA) for data processing to generate linkage maps and draft genomes. Using SELDLA, linkage maps and improved genomes for two species of pufferfish, Takifugu rubripes and Takifugu stictonotus, were obtained simultaneously. The strategy is applicable to a wide range of sexually reproducing organisms, and could, therefore, accelerate the whole genome analysis of various organisms including fish, mollusks, amphibians, insects, plants, and even mammals.
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Registered trials
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