Evidence map›Paper›PMID 30382093›Full record

ArticleNature communications2018

Calcium sensing by the STIM1 ER-luminal domain.

Aparna Gudlur, Ana Eliza Zeraik, Nupura Hirve, V Rajanikanth, Andrey A Bobkov, Guolin Ma, Sisi Zheng, Youjun Wang, Yubin Zhou, Elizabeth A Komives and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
  2. Listening to the quiescence of single STIM1 dimers.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Multiple weak brakes act in concert to control STIM1 and store-operated calcium entry.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. STIM1 transmembrane helix dimerization captured by AI-guided transition path sampling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Essential role of N-terminal SAM regions in STIM1 multimerization and function.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Aparna GudlurDivision of Signalling and Gene Expression, La Jolla Institute for Allergy & Immunology, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0001-8753-183X
Ana Eliza ZeraikDivision of Signalling and Gene Expression, La Jolla Institute for Allergy & Immunology, La Jolla, CA, 92037, USA.
Nupura HirveDivision of Signalling and Gene Expression, La Jolla Institute for Allergy & Immunology, La Jolla, CA, 92037, USA.
V RajanikanthDivision of Signalling and Gene Expression, La Jolla Institute for Allergy & Immunology, La Jolla, CA, 92037, USA.
Andrey A BobkovProtein Production and Analysis Facility, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Guolin MaCenter for Translational Cancer Research, Institute of Biosciences & Technology, College of Medicine, Texas A&M University, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0001-5460-3446
Sisi ZhengBeijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.ORCID http://orcid.org/0000-0001-9283-4472
Youjun WangBeijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.ORCID http://orcid.org/0000-0003-0961-1716
Yubin ZhouCenter for Translational Cancer Research, Institute of Biosciences & Technology, College of Medicine, Texas A&M University, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0001-7962-0517
Elizabeth A KomivesDepartment of Chemistry and Biochemistry, University of California-San Diego, La Jolla, CA, 92037, USA.
Patrick G HoganDivision of Signalling and Gene Expression, La Jolla Institute for Allergy & Immunology, La Jolla, CA, 92037, USA. phogan@lji.org.

Funding

SIGNAL TRANSDUCTION AND GENE INDUCTION IN T LYMPHOCYTESR01AI040127 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK, RAO, ANJANA · 1996 to 2025
$13.3M
NFAT, bZIP proteins, and transcriptional programs in lymphocytesR01AI109842 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Patrick Hogan, Anjana Rao · 2014 to 2026
$8.6M
STIM-ORAI signaling and other calcium influx pathways in lymphocytesR01AI084167 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK · 2009 to 2019
$4.9M
MOLECULAR CONTROL OF CALCIUM INFLUX AT THE ER-PLASMA MEMBRANE JUNCTIONSR01GM112003 · NIGMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ZHOU, YUBIN · 2014 to 2022
$2.7M
Nanoscale regulation of store-operated calcium entry through STIM-ORAI signallingR01GM110397 · NIGMS · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK, LILLEMEIER, BJOERN F · 2014 to 2017
$1.4M
Acquisition of an Orbitrap Elite with ETDS10OD021724 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 2016 to 2016
$600k
Optogenetic toolkit for remote control of voltage-gated calcium channelsR21GM126532 · NIGMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI HAN, GANG, ZHOU, YUBIN · 2018 to 2019
$443k
NIAID NIH HHS R01 AI040127NIAID NIH HHS R01 AI084167NIAID NIH HHS R01 AI109842NIGMS NIH HHS R01 GM110397NIGMS NIH HHS R01 GM112003NIGMS NIH HHS R21 GM126532NIH HHS S10 OD021724
6 · The paper itself

Abstract

Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca

Indexed as

AnimalsBinding SitesCalciumCalorimetryCysteineDeuterium Exchange MeasurementEndoplasmic ReticulumFluorescenceHeLa CellsHumansMiceMutationProtein DomainsProtein Structure, SecondarySolubilityStromal Interaction Molecule 1CalciumCysteineStromal Interaction Molecule 1

Identifiers

PMID30382093
PMCPMC6208404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.