Evidence map›Paper›PMID 30381987›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2019

International consensus on quality standards for brain health-focused care in multiple sclerosis.

Jeremy Hobart, Amy Bowen, George Pepper, Harriet Crofts, Lucy Eberhard, Thomas Berger, Alexey Boyko, Cavit Boz, Helmut Butzkueven, Elisabeth Gulowsen Celius and 17 more

2 registry-linked trialsOpen access · hybridAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04388592 nacompletednot on this map

MS Wellness Navigator: The Effect of Nurse Practitioner (NP-led) Care on Mood, Anxiety and Health Related Quality of Life in People With Multiple Sclerosis - A Randomized Trial

TypeinterventionalSponsorUniversity of AlbertaRan2017 to 2019Enrolled248ConditionsMultiple Sclerosis, Nurse's RoleArmsNurse Practitioner (NP) Led Care Arm
NCT04979546 nacompletednot on this mapstarted 2021, after this paper: background citation

Using Patient-Reported Outcomes To Improve the Care of People With Multiple Sclerosis: A Randomized Trial

TypeinterventionalSponsorUniversity of AlbertaRan2021 to 2024Enrolled237ConditionsMultiple Sclerosis, Anxiety, Depression, Patient SatisfactionArmsIntensive Use of Patient Reported Outcome Measures and Open PROM Availability to Treating Neurologist, Conservative Use of Patient Reported Outcome Measures and Blinded PROM Availability to Treating Neurologist
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. A smartphone sensor-based digital outcome assessment of multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022
    Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Review
  17. Consensus quality indicators for monitoring multiple sclerosis.The Lancet regional health. Europe · 2024
    Review
  18. Article
  19. Article
  20. Diagnostic delay of multiple sclerosis: prevalence, determinants and consequences.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 18 countries.

Jeremy HobartPlymouth University Peninsula Schools of Medicine and Dentistry, University of Plymouth, Plymouth, UK.
Amy BowenNHS RightCare, NHS England, London, UK.
George PepperShift.ms, Leeds, UK.
Harriet CroftsPharmaGenesis London, London, UK.
Lucy EberhardPharmaGenesis London, London, UK.
Thomas BergerClinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Alexey BoykoDepartment of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University, Moscow, Russia/Demyelinating Diseases Center, Yusupov Hospital, Moscow, Russia.
Cavit BozDepartment of Neurology, Karadeniz Technical University, Trabzon, Turkey.
Helmut ButzkuevenMS and Neuroimmunology Unit, Alfred Health and Eastern Health, Monash University, Melbourne, VIC, Australia.
Elisabeth Gulowsen CeliusDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Jelena DrulovicDepartment for Immune-Mediated Disorders of the Central Nervous System, Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
José FloresNational Institute of Neurology and Neurosurgery, ABC Medical Center, Mexico City, Mexico.
Dana HorákováDepartment of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Christine Lebrun-FrénayCRCSEP Neurologie Pasteur 2, Université Côte d'Azur, Nice, France.
Ruth Ann MarrieDepartments of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
James OverellGlasgow MS Clinical Research Centre, Queen Elizabeth University Hospital, Glasgow, UK.
Fredrik PiehlDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Peter Vestergaard RasmussenDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Maria José SáMS Clinic, Department of Neurology, Centro Hospitalar São João, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal.
Carmen-Adella SîrbuClinic of Neurology, Central Military Emergency University Hospital, Bucharest, Romania.
Eli SkromneInstituto Mexicano de Neurociencias, Hospital Angeles Lomas, Mexico City, Mexico.
Øivind TorkildsenDepartment of Neurology, Haukeland University Hospital, Bergen, Norway.
Vincent van PeschCliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Timothy VollmerDepartment of Neurology, University of Colorado, Denver, CO, USA.
Magd ZakariaDepartment of Neurology, Ain Shams University, Cairo, Egypt.
Tjalf ZiemssenDepartment of Neurology, MS Center Dresden, Center of Clinical Neuroscience, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
Gavin GiovannoniQueen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK.
Aarhus University Hospital · DKAin Shams University · EGCharles University · CZCliniques Universitaires Saint-Luc · BEFernando Pessoa University · PTHaukeland University Hospital · NOInstituto Nacional de Neurología y Neurocirugía · MXKaradeniz Technical University · TRKarolinska Institutet · SEMonash University · AUNHS EnglandOslo University Hospital · NOPirogov Russian National Research Medical University · RUQueen Elizabeth University Hospital · GBQueen Mary University of London · GBShift (United Kingdom) · GBUniversität Innsbruck · ATUniversité Côte d'Azur · FRUniversity Hospital Carl Gustav Carus · DEUniversity of Belgrade · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTime matters in multiple sclerosis (MS). Irreversible neural damage and cell loss occur from disease onset. The MS community has endorsed a management strategy of prompt diagnosis, timely intervention and regular proactive monitoring of treatment effectiveness and disease activity to improve outcomes in people with MS.

objectivesWe sought to develop internationally applicable quality standards for timely, brain health-focused MS care.

methodsA panel of MS specialist neurologists participated in an iterative, online, modified Delphi process to define 'core', 'achievable' and 'aspirational' time frames reflecting minimum, good and high care standards, respectively. A multidisciplinary Reviewing Group (MS nurses, people with MS, allied healthcare professionals) provided insights ensuring recommendations reflected perspectives from multiple stakeholders.

resultsTwenty-one MS neurologists from 19 countries reached consensus on most core (25/27), achievable (25/27) and aspirational (22/27) time frames at the end of five rounds. Agreed standards cover six aspects of the care pathway: symptom onset, referral and diagnosis, treatment decisions, lifestyle, disease monitoring and managing new symptoms.

conclusionThese quality standards for core, achievable and aspirational care provide MS teams with a three-level framework for service evaluation, benchmarking and improvement. They have the potential to produce a profound change in the care of people with MS.

Indexed as

BrainMultiple SclerosisDelphi TechniqueHumansNeurologybenchmarkingconsensusDelphi techniqueMultiple sclerosisquality improvementstandards

Identifiers

PMID30381987
PMCPMC6826858
OpenAlexW2899172313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.