Evidence map›Paper›PMID 30381945›Full record

ArticleBiochemistry2018

A Sensitive, Nonradioactive Assay for Zn(II) Uptake into Metazoan Cells.

Christopher E R Richardson, Elizabeth M Nolan, Matthew D Shoulders, Stephen J Lippard

Abstract readValidation Study
In one paragraph

Article in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Albumin-mediated extracellular zinc speciation drives cellular zinc uptake.Chemical communications (Cambridge, England) · 2022
    Article
  3. Tools and techniques for illuminating the cell biology of zinc.Biochimica et biophysica acta. Molecular cell research · 2021
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christopher E R RichardsonDepartment of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.
Elizabeth M NolanDepartment of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.ORCID 0000-0002-6153-8803
Matthew D ShouldersDepartment of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.ORCID 0000-0002-6511-3431
Stephen J LippardDepartment of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.ORCID 0000-0002-2693-4982

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Paula T Hammond · 1985 to 2026
$93.9M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YAFFE, MICHAEL B · 1985 to 2020
$25.6M
Investigation of Zinc Neurochemistry by Optical Sensing and MRIR01GM065519 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NOLAN, ELIZABETH M · 2002 to 2017
$5.3M
Supplement to Neurobiological Engineering Training ProgramT32EB019940 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JASANOFF, ALAN · 2015 to 2025
$1.4M
NCI NIH HHS P30 CA014051NIBIB NIH HHS T32 EB019940NIEHS NIH HHS P30 ES002109NIGMS NIH HHS R01 GM065519
6 · The paper itself

Abstract

Sensitive measurements of cellular Zn(II) uptake currently rely on quantitating radioactive emissions from cells treated with

Indexed as

Binding, CompetitiveBiological Transport, ActiveCadmiumCation Transport ProteinsCell LineHEK293 CellsHeLa CellsHep G2 CellsHumansKineticsMass SpectrometryRecombinant ProteinsSensitivity and SpecificityZincZinc IsotopesCadmiumCation Transport ProteinsRecombinant ProteinsZincZinc Isotopes

Identifiers

PMID30381945
PMCPMC6437758

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.