Evidence map›Paper›PMID 30381805›Full record

ArticleJournal of immunological techniques in infectious diseases2016

Infection and Activation of Human Neutrophils with Fluorescent

R E Davis, C J Thalhofer, M E Wilson

Abstract read
In one paragraph

Article in Journal of immunological techniques in infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Oxidative Stress and Survival ofExpert reviews in molecular medicine · 2025
    Review
  2. Microorganisms · 2022
    Article
  3. Frontiers in cellular and infection microbiology · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

R E DavisInterdisciplinary Program in Immunology, University of Iowa, Iowa City, IA, USA.
C J ThalhoferAgonox Inc., Portland, OR 97213.
M E WilsonInterdisciplinary Program in Immunology, University of Iowa, Iowa City, IA, USA.

Funding

PREDOCTORAL TRAINING PROGRAM IN IMMUNOLOGYT32AI007485 · NIAID · UNIVERSITY OF IOWA · PI Kevin L Legge · 1995 to 2026
$5.4M
Protective Immunity to Leishmania chagasiR01AI045540 · NIAID · UNIVERSITY OF IOWA · PI WILSON, MARY E · 2001 to 2011
$3.1M
Genetic Risk Factors for Visceral LeishmaniasisR01AI076233 · NIAID · UNIVERSITY OF IOWA · PI BLACKWELL, JENEFER MARY, WILSON, MARY E · 2009 to 2013
$1.6M
The Role of Exosomes in the Pathogenesis of LeishmaniasisI01BX000536 · VA · IOWA CITY VA MEDICAL CENTER · PI WILSON, MARY E · 2009 to 2023
–
Innate inflammatory cells in leishmaniasisI01BX001983 · VA · IOWA CITY VA MEDICAL CENTER · PI WILSON, MARY E · 2014 to 2022
–
BLRD VA I01 BX000536BLRD VA I01 BX001983NIAID NIH HHS R01 AI045540NIAID NIH HHS R01 AI076233NIAID NIH HHS T32 AI007485
6 · The paper itself

Abstract

Neutrophils (PMNs) are recruited in high numbers to sites of host infection by the protozoan parasites of the genus Leishmania. Although PMNs are capable of phagocytizing Leishmania parasites and are potent producers of anti-microbial compounds including reactive oxygen species (ROS), they are unable to control the establishment of infection. Prior studies document production of ROS in isolated PMNs incubated with Leishmania under conditions allowing phagocytosis, but without a measure of single cells' responses it cannot be discerned whether PMN activation and ROS production is suppressed or ineffective in the cells that internalize the parasite. To address these interactions, we engineered a strain of fluorescent, mCherry-expressing

Indexed as

Flow cytometryLeishmaniaNeutrophils

Identifiers

PMID30381805
PMCPMC6205212

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.