Evidence map›Paper›PMID 30381783›Full record

ArticleAdvances in inorganic chemistry2016

Opportunities and challenges for metal chemistry in molecular imaging: from gamma camera imaging to PET and multimodality imaging.

Richard Southworth, Rafael Torres Martin de Rosales, Levente K Meszaros, Michelle T Ma, Gregory E D Mullen, Gilbert Fruhwirth, Jennifer D Young, Cinzia Imberti, Julia Bagunya-Torres, Erica Andreozzi and 1 more

Abstract read
In one paragraph

Article in Advances in inorganic chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Cold Kit Labeling: The Future ofFrontiers in medicine · 2022
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Richard SouthworthKing's College London, Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, London, UK.
Rafael Torres Martin de RosalesKing's College London, Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, London, UK.
Levente K MeszarosKing's College London, Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, London, UK.
Michelle T MaKing's College London, Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, London, UK.
Gregory E D MullenKing's College London, Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, London, UK.
Gilbert FruhwirthKing's College London, Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, London, UK.
Jennifer D YoungKing's College London, Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, London, UK.
Cinzia ImbertiKing's College London, Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, London, UK.
Julia Bagunya-TorresKing's College London, Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, London, UK.
Erica AndreozziKing's College London, Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, London, UK.
Philip J BlowerKing's College London, Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, London, UK.

Funding

Cancer Research UK A16463Medical Research Council MC_PC_14105Wellcome Trust 084052Wellcome Trust 088641
6 · The paper itself

Abstract

The development of medical imaging is a highly multidisciplinary endeavor requiring the close cooperation of clinicians, physicists, engineers, biologists and chemists to identify capabilities, conceive challenges and solutions and apply them in the clinic. The chemistry described in this article illustrates how synergistic advances in these areas drive the technology and its applications forward, with each discipline producing innovations that in turn drive innovations in the others. The main thread running through the article is the shift from single photon radionuclide imaging towards PET, and in turn the emerging shift from PET/CT towards PET/MRI and further, combination of these with optical imaging. Chemistry to support these transitions is exemplified by building on a summary of the status quo, and recent developments, in technetium-99m chemistry for SPECT imaging, followed by a report of recent developments to support clinical application of short lived (Ga-68) and long-lived (Zr-89) positron emitting isotopes, copper isotopes for PET imaging, and combined modality imaging agents based on radiolabelled iron oxide based nanoparticles.

Indexed as

contrast agentscoppergalliumpositron emission tomographyradiopharmaceuticalstechnetiumzirconium

Identifiers

PMID30381783
PMCPMC6205628

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.