Evidence map›Paper›PMID 30381543›Full record

ArticleThe Indian journal of medical research2018

Effect of vitamin D supplementation on sustained virological response in genotype 1/4 chronic hepatitis C treatment-naïve patients from India.

Manas Kumar Behera, Sunit Kumar Shukla, Vinod Kumar Dixit, Preetam Nath, V B Abhilash, Pankaj Kumar Asati, Ashok Kumar Jain

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Indian journal of medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Vitamin D supplementation for chronic liver diseases in adults.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Manas Kumar BeheraDepartment of Gastroenterology, Kalinga Institute of Medical Sciences, Bhubaneswar, India.
Sunit Kumar ShuklaDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Vinod Kumar DixitDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Preetam NathDepartment of Gastroenterology, SCB Medical College, Cuttack, India.
V B AbhilashDepartment of Gastroenterology, ESIC, Model & Super Specialty Hospital, Kollam, India.
Pankaj Kumar AsatiDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Ashok Kumar JainDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Institute of Medical Sciences · INAll India Institute of Medical Sciences Bhubaneswar · INBanaras Hindu University · INSriram Chandra Bhanja Medical College Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

objectivesThe effect of vitamin D supplementation on response to antiviral therapy in hepatitis C virus (HCV) genotype 1 and 4 infection still remains unclear, with studies yielding inconsistent results. The aim of the present study was to assess the effect of vitamin D supplementation on treatment outcome in patients with genotype 1/4 chronic hepatitis C (CHC) infection.

methodsSixty consecutive, treatment-naïve, genotype 1 and 4 chronic HCV patients were included in the study. The patients were randomized into two groups: Vitamin D supplemented group received pegylated (PEG)-interferon α-2a 180 μg per week plus ribavirin (RBV) (1000-1200 mg/d) together with vitamin D3 (2000 IU/d) and control group received identical therapy without vitamin D (32 patients).

resultsThere were no significant differences between the two groups in terms of age, sex, body mass index and baseline laboratory values. Lower vitamin D levels were associated with higher grades of fibrosis in liver histology (vitamin D >20 ng/ml - 70% vs vitamin D <20 ng/ml - 37%, P<0.05). Vitamin D supplemented group had similar rapid viral response (40 vs 28%, P=0.36), complete early viral response (53.2 vs 40%, P=0.34), end of treatment response (64 vs 46%, P=0.17) and sustained virological response (SVR) (60 vs 44%, P=0.19) as compared to control group. Interleukin 28B polymorphism [odds ratio (OR)-15.37, 95% confidence interval (CI)-2.32-101.76, P=0.04] and baseline serum vitamin D levels (OR-6.36, 95% CI-1.36-29.61 P=0.02) were independent predictors of SVR in genotype 1/4 CHC. Vitamin D supplementation was not found to be predictor of response in genotype 1/4 CHC on multivariate analysis (OR-2.79, 95% CI- 0.63-12.34, P=0.74). INTERPRETATION &

conclusionsThe present study showed that addition of vitamin D to PEG/RBV combination therapy in treatment-naïve patients who were infected with HCV genotype 1/4 had no effect on the rates of rapid, early and sustained viral responses.

Indexed as

Dietary SupplementsAdultFemaleGenotypeHepacivirusHepatitis C, ChronicHumansIndiaInterferon-alphaLiverMaleMiddle AgedPolyethylene GlycolsRecombinant ProteinsRibavirinRNA, ViralInterferon-alphapeginterferon alfa-2aPolyethylene GlycolsRecombinant ProteinsRibavirinRNA, ViralVitamin DGenotypehepatitis C interleukin 28B polymorphismliver fibrosissustained virological responsevitamin D

Identifiers

PMID30381543
PMCPMC6206764
OpenAlexW2896231105

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.