ArticleBMJ (Clinical research ed.)2018
Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study.
Article in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed.
- Age-period-cohort analysis of low birth weight, early-term delivery, induction, and cesarean-section, US births 1990-2019.American journal of epidemiology · 2026Article
- Interactive Effects of Parental Age on Adverse Birth Outcomes in Japan: An Investigation of Nationwide Birth Data.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026Article
- Adipose-Derived Mesenchymal Stem Cells Alleviate ᴅ-Galactose-Induced Testicular Injury by Activating the Keap1/Nrf2 Pathway and Suppressing NLRP3-Associated Pyroptosis.Antioxidants (Basel, Switzerland) · 2026Article
- Parental age and its influence on functional dependency and cognitive decline in older adults: a cohort analysis.Journal of health, population, and nutrition · 2026Article
- Incidence of psychotic disorders by birth cohort: a population-based cohort study in Ontario, Canada.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Conserved shifts in sperm small non-coding RNA profiles during mouse and human aging.The EMBO journal · 2026Article
- Cross-country comparison of perinatal outcomes between japanese mothers in the united states and japan: a cross-sectional study.BMJ public health · 2026Article
- Modeling dynamic velocity-based gestational weight gain trajectories in advanced maternal age: association with perinatal outcomes.Frontiers in medicine · 2026Article
- From the Atacama to Patagonia: Understanding the Effects of Extreme Temperatures on Birth Weight Across Climate Regions in Chile.GeoHealth · 2025Article
- [Restoration of ejaculate quality following androgen replacement and combined therapy for hypogonadism].Problemy endokrinologii · 2025Observational
- Review
- Deciphering the Contribution of Circular RNAs to Age-Related Decline in Sertoli Cell Survivor.Aging cell · 2025Article
- PREGNANCY DISORDERS AND MATERNAL CONSEQUENCES: Maternal pre-pregnancy risks and postpartum consequences of gestational diabetes.Reproduction (Cambridge, England) · 2025Review
- Single-Cell Transcriptomics Uncovers Core Signature for Regulating Mitochondrial Homeostasis During Testicular Ageing.Cell proliferation · 2025Article
- The high-priority ethical issues of advanced paternal age: perspectives from a panel of experts in the fields of men reproduction and family building.BMC medical ethics · 2025Article
- Classification and identification of risk factors for type 2 diabetes.World journal of diabetes · 2025Review
- Association of paternal preconception hepatitis B virus infection with the risk of preterm birth between 2010 and 2020 in China: a population-based cohort study.BMJ public health · 2025Article
- Paternal age and neonatal outcomes: a population-based cohort study.Human reproduction open · 2025Article
- Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal-paternal-child triad.Pediatric obesity · 2024Article
- Associations of paternal age with offspring under-five mortality and perinatal outcomes: a cohort study using claims data in Taiwan.BMJ public health · 2024Article
22 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
Abstract
objectiveTo evaluate the impact of advanced paternal age on maternal and perinatal outcomes in the United States.
designRetrospective, population based cohort study.
settingUS. POPULATION: 40 529 905 documented live births between 2007 and 2016.
main outcome measuresPrimary perinatal outcomes were gestational age, birth weight, Apgar score at five minutes, admission to a neonatal intensive care unit, need for postpartum antibiotics, and seizures. Primary maternal outcomes were gestational diabetes and pre-eclampsia. Secondary outcome was the number of preventable perinatal events.
resultsHigher paternal age was associated with an increased risk of premature birth, low birth weight, and low Apgar score. After adjustment for maternal age, infants born to fathers aged 45 years or older had 14% higher odds of premature birth (odds ratio 1.14, 95% confidence interval 1.13 to 1.15), independent of gestational age, and 18% higher odds of seizures (1.18, 0.97 to 1.44) compared with infants of fathers aged 25 to 34 years. The odds of gestational diabetes was 34% higher (1.34, 1.29 to 1.38) in mothers with the oldest partners. 13.2% (95% confidence interval 12.5% to 13.9%) of premature births and 18.2% (17.5% to 18.9%) of gestational diabetes in births associated with older fathers were estimated to be attributable to advanced paternal age.
conclusionsAdvanced paternal age is associated with negative effects on both mothers and offspring. Given the relatively low prevalence of advanced paternal age in the US, population level impacts are currently modest. Nevertheless, as advanced paternal age has doubled in the US over the past generation, further investigation is warranted of the impact on birth outcomes and public health.
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