Evidence map›Paper›PMID 30381461›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

In vivo 3'-to-5' exoribonuclease targetomes of

Anne-Laure Lécrivain, Anaïs Le Rhun, Thibaud T Renault, Rina Ahmed-Begrich, Karin Hahnke, Emmanuelle Charpentier

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Structural insights into RNA recognition by theProceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Anne-Laure LécrivainMax Planck Unit for the Science of Pathogens, D-10117 Berlin, Germany.ORCID 0000-0001-8957-3857
Anaïs Le RhunMax Planck Unit for the Science of Pathogens, D-10117 Berlin, Germany.ORCID 0000-0003-2211-2153
Thibaud T RenaultMax Planck Unit for the Science of Pathogens, D-10117 Berlin, Germany.ORCID 0000-0002-1530-2613
Rina Ahmed-BegrichMax Planck Unit for the Science of Pathogens, D-10117 Berlin, Germany.
Karin HahnkeMax Planck Unit for the Science of Pathogens, D-10117 Berlin, Germany.
Emmanuelle CharpentierMax Planck Unit for the Science of Pathogens, D-10117 Berlin, Germany; research-charpentier@mpiib-berlin.mpg.de.ORCID 0000-0002-0254-0778
Max Planck Institute for Infection Biology · DEHumboldt-Universität zu Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

mRNA decay plays an essential role in the control of gene expression in bacteria. Exoribonucleases (exoRNases), which trim transcripts starting from the 5' or 3' end, are particularly important to fully degrade unwanted transcripts and renew the pool of nucleotides available in the cell. While recent techniques have allowed genome-wide identification of ribonuclease (RNase) targets in bacteria in vivo, none of the 3'-to-5' exoRNase targetomes (i.e., global processing sites) have been studied so far. Here, we report the targetomes of YhaM, polynucleotide phosphorylase (PNPase), and RNase R of the human pathogen

Indexed as

ExoribonucleasesGene Expression Regulation, BacterialPolyribonucleotide NucleotidyltransferaseRNA, BacterialRNA, MessengerRNA StabilityStreptococcus pyogenesExoribonucleasesPolyribonucleotide Nucleotidyltransferaseribonuclease RRNA, BacterialRNA, Messenger3′-end sequencing3′-to-5′ exoRNase5′-end sequencingRNA degradationStreptococcus pyogenes

Identifiers

PMID30381461
PMCPMC6243249
OpenAlexW2898673795

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.