Evidence map›Paper›PMID 30381397›Full record

ArticleThe Journal of biological chemistry2018

Adapted ATPase domain communication overcomes the cytotoxicity of p97 inhibitors.

Yang Wei, Julia I Toth, Gabrielle A Blanco, Andrey A Bobkov, Matthew D Petroski

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Science advances · 2023
    Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yang WeiFrom the NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037.
Julia I TothFrom the NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037.
Gabrielle A BlancoFrom the NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037.
Andrey A BobkovFrom the NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037.
Matthew D PetroskiFrom the NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037. Electronic address: petroski@sbpdiscovery.org.
Discovery Institute · USSanford Burnham Prebys Medical Discovery Institute · US

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2M
(PQD1) Treatment-emergent resistance to NEDD8-activating enzyme inhibitionR01CA180150 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI PETROSKI, MATTHEW · 2013 to 2016
$2.3M
Assay Development for the Identification of NEDD8- activating Enzyme InhibitorsR01CA185300 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI PETROSKI, MATTHEW · 2015 to 2017
$1.3M
NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA180150NCI NIH HHS R01 CA185300
6 · The paper itself

Abstract

The AAA

Indexed as

Adenosine TriphosphatasesMutation, MissenseValosin Containing ProteinAmino Acid SubstitutionHCT116 CellsHumansIndolesProtein DomainsPyrimidinesAdenosine TriphosphatasesCB-5083IndolesPyrimidinesValosin Containing ProteinATPases associated with diverse cellular activities (AAA)proteasomeprotein degradationprotein homeostasisprotein quality controlprotein unfoldingubiquitin

Identifiers

PMID30381397
PMCPMC6311501
OpenAlexW2899354376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.